Table 6 Interactions between polymorphisms in genes that are associated with IGM or T2DM at the three FDR levels.
Block Pair/Chrom.Loc. Or SNP Pair/Gene Pair | FDR = 0.125 | FDR = 0.461 | ||
|---|---|---|---|---|
| Â | IGM | T2DM | IGM | T2DM |
(1,5)/(1,5) | Â | Â | Â | Â |
(V4:V15)/(NPPA:ADRB2) | -- | -- | Down | Down |
(V7:V16)/(SELE:ITGA2) | -- | Up | -- | Up |
(2,10)/(2,12) | Â | Â | Â | Â |
(V8:V49)/(APOB:SCNN1A) | Down | Down | Down | Down |
(V8:V50)/(APOB:GNB3) | -- | Up | -- | Up |
(2,13)/(2,16) | Â | Â | Â | Â |
(V8:V56)/(APOB:CETP) | -- | Up | -- | Up |
(5,16)/(5,21) | Â | Â | Â | Â |
(V15:V67)/(ADRB2:CBS) | -- | Up | -- | Up |
(6,10)/(6,12) | Â | Â | Â | Â |
(V18:V50)/(LPA:GNB3) | -- | -- | Down | Down |
(V21:V48)/(TNF:SCNN1A) | -- | -- | Up | -- |
(6,11)/(6,13) | Â | Â | Â | Â |
(V18:V51)/(LPA:F7) | Up | -- | Up | -- |
(V18:V52)/(LPA:F7) | Up | -- | Up | -- |
(6,16)/(6,21) | Â | Â | Â | Â |
(V18:V67)/(LPA:CBS) | Down | Down | Down | Down |
(7,12)/(7,15) | Â | Â | Â | Â |
(V28:V53)/(NOS3:LIPC) | -- | -- | -- | Up |
(V30:V53)/(NOS3:LIPC) | -- | -- | Down | -- |
(8,14)/(8,17) | Â | Â | Â | Â |
(V34:V62)/(LPL:ITGB3) | -- | -- | Up | -- |
(V37:V62)/(LPL:ITGB3) | -- | -- | -- | Up |
(9,11)/(11,13) | Â | Â | Â | Â |
(V39:V51)/(APOA4:F7) | -- | -- | -- | Up |
(V39:V52)/(APOA4:F7) | -- | -- | -- | Up |
(V41:V51)/(APOC3:F7) | -- | -- | Down | Down |
(V43:V51)/(APOC3:F7) | Down | Down | Down | Down |
(12,13)/(15,16) | Â | Â | Â | Â |
(V53:V56)/(LIPC:CETP) | -- | -- | Down | Down |
(V53:V60)/(LIPC:CETP) | -- | -- | Down | -- |
(13,15)/(16,19) | Â | Â | Â | Â |
(V56:V64)/(CETP:APOE) | -- | -- | -- | Up |
(V54:V65)/(CETP:LDLR) | -- | -- | -- | Up |
(V55:V65)/(CETP:LDLR) | -- | -- | Down | Down |
(V56:V63)/(CETP:APOE) | -- | -- | Up | -- |
(V60 :V65)/(CETP:LDLR) | -- | -- | Down | -- |
(14,16)/(17,21) | Â | Â | Â | Â |
(V62:V67)/(ITGB3:CBS) | Up | -- | Up | -- |
(9,9)/(11,11) | Â | Â | Â | Â |
(V38, V43)/(APOA4:APOC3) | -- | Up | Up | Up |
(V39:V40)/(APOA4:APOC3) | Up | Up | Up | Up |
(V39:V42)/(APOA4:APOC3) | -- | -- | Up | Up |
(V42:V43)/(APOC3:APOC3) | Up | -- | Up | -- |
(10,10)/(12,12) | Â | Â | Â | Â |
(V48:V49)/(SCNN1A:SCNN1A) | Up | -- | Up | Up |
# Pairs implicated in either IGM or T2DM or both (disturbed glucose metabolism) | 14 | Â | 32 | Â |