BMC Medical Genetics

Table 6 Allele frequencies and Hazard Rate Ratios for incident CAD for minor alleles of LOX 1.2, LOX 1.3 in the Atherosclerosis Risk In Communities study

From: Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD

				Recessive		Additive		Dominant
	geno	Cases	Non-cases	model 1	model 2	model 1	model 2	model 1	model 2
		counts (%)	counts (%)	HR CI	HR CI	HR CI	HR CI	HR CI	HR CI
LOX 1.2
Whites	GG	938 (81)	7075 (81)
	CG	204 (18)	1549 (18)	1.22 0.7–2.1	1.23 0.7–2.1	1.01 0.88–1.2	0.99 0.86–1.1	1 0.86–1.2	0.97 0.84–1.1
	CC	14 (1)	78 (1)
	Total	1156	8702
AA	GG	185 (59)	1841 (60)
	CG	118 (38)	1056 (35)	0.72 0.4–1.3	0.79 0.4–1.4	1 0.83–1.2	0.98 0.8–1.2	1.05 0.84–1.3	1.01 0.8–1.3
	CC	11 (3)	156 (5)
	Total	314	3053
All	GG	1123 (76)	8916 (76)
	CG	322 (22)	2065 (18)	0.95 0.64–1.4	1.0 0.7–1.5	1.01 0.9–1.1	0.99 0.88–1.1	1.01 0.9–1.1	0.99 0.88–1.1
	CC	25 (2)	234 (2)
	Total	1470	11755
LOX1.3
Whites	GG	342 (30)	2393 (27)
	GC	560 (48)	4329 (50)	0.93 0.81–1.1	0.93 0.81–1.1	0.93 0.86–1.0	0.94 0.87–1.0	0.9, 0.8–1.0	0.91 0.8–1.0
	CC	250 (22)	1970 (23)
	Total	1152	8692
AA	GG	236 (74)	2099 (69)
	GC	72 (23)	818 (27)	0.79 0.4–1.5	0.93 0.5–1.8	0.81 0.65–1.0	0.85 0.68–1.1	0.78 0.6–1.0	0.81 0.63–1.0
	CC	10 (3)	124 (4)
	Total	318	3041
All	GG	578 (39)	4492 (38)
	GC	632 (43)	5147 (44)	0.92 0.8–1.1	0.93 0.81–1.1	0.92* 0.85–0.99	0.92* 0.86–1.0	0.87* 0.78–0.97	0.89* 0.79–0.99
	CC	260 (18)	2094 (18)
	Total	1470	11733

Model 1: adjusted for age and gender (and race in non-stratified analyses).
Model 2: adjusted for age, gender, center, HDL and total cholesterol, BMI, smoking, diabetes and hypertension status (and race in non-stratified analyses). * P < 0.05

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