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Table 6 Allele frequencies and Hazard Rate Ratios for incident CAD for minor alleles of LOX 1.2, LOX 1.3 in the Atherosclerosis Risk In Communities study

From: Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD

     Recessive Additive Dominant
  geno Cases Non-cases model 1 model 2 model 1 model 2 model 1 model 2
   counts (%) counts (%) HR
CI
HR
CI
HR
CI
HR
CI
HR
CI
HR
CI
LOX 1.2          
Whites GG 938 (81) 7075 (81)       
  CG 204 (18) 1549 (18) 1.22
0.7–2.1
1.23
0.7–2.1
1.01
0.88–1.2
0.99
0.86–1.1
1
0.86–1.2
0.97
0.84–1.1
  CC 14 (1) 78 (1)       
  Total 1156 8702       
AA GG 185 (59) 1841 (60)       
  CG 118 (38) 1056 (35) 0.72
0.4–1.3
0.79
0.4–1.4
1
0.83–1.2
0.98
0.8–1.2
1.05
0.84–1.3
1.01
0.8–1.3
  CC 11 (3) 156 (5)       
  Total 314 3053       
All GG 1123 (76) 8916 (76)       
  CG 322 (22) 2065 (18) 0.95
0.64–1.4
1.0
0.7–1.5
1.01
0.9–1.1
0.99
0.88–1.1
1.01
0.9–1.1
0.99
0.88–1.1
  CC 25 (2) 234 (2)       
  Total 1470 11755       
LOX1.3          
Whites GG 342 (30) 2393 (27)       
  GC 560 (48) 4329 (50) 0.93
0.81–1.1
0.93
0.81–1.1
0.93
0.86–1.0
0.94
0.87–1.0
0.9,
0.8–1.0
0.91
0.8–1.0
  CC 250 (22) 1970 (23)       
  Total 1152 8692       
AA GG 236 (74) 2099 (69)       
  GC 72 (23) 818 (27) 0.79
0.4–1.5
0.93
0.5–1.8
0.81
0.65–1.0
0.85
0.68–1.1
0.78
0.6–1.0
0.81
0.63–1.0
  CC 10 (3) 124 (4)       
  Total 318 3041       
All GG 578 (39) 4492 (38)       
  GC 632 (43) 5147 (44) 0.92
0.8–1.1
0.93
0.81–1.1
0.92*
0.85–0.99
0.92*
0.86–1.0
0.87*
0.78–0.97
0.89*
0.79–0.99
  CC 260 (18) 2094 (18)       
  Total 1470 11733       
  1. Model 1: adjusted for age and gender (and race in non-stratified analyses).
  2. Model 2: adjusted for age, gender, center, HDL and total cholesterol, BMI, smoking, diabetes and hypertension status (and race in non-stratified analyses). * P < 0.05