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Table 1 Association between single nucleotide polymorphisms in leukotriene pathway candidate genes and chronic rhinosinusitis.

From: Influence of leukotriene gene polymorphisms on chronic rhinosinusitis

Gene (chr)

SNPs

MAF

Minor allele

HWE p value

Case, Control Ratios**

p value

ALOX5AP (13)

rs12430915

0.08

C

0.200

38:378, 26:346

0.271

 

rs4769870

0.16

T

0.080

353:61, 269:61

0.170

 

rs4076128

0.30

C

0.439

290:124, 255:111

0.909

 

rs11616333

0.05

G

0.558

22:396, 19:353

0.922

 

rs4769055

0.33

A

0.187

143:275, 120:252

0.561

 

rs9578196

0.10

T

0.408

380:38, 326:42

0.283

 

rs4293222

0.37

C

0.930

161:257, 134:236

0.505

 

rs12429692

0.26

T

1.000

118:300, 88:284

0.144

 

rs10162089

0.49

T

0.828

217:197, 184:186

0.453

 

rs4254165

0.28

C

0.928

302:114, 264:108

0.612

 

rs4356336

0.42

C

1.000

242:176, 208:154

0.902

 

rs17612127

0.08

T

0.847

40:376, 21:343

0.046

 

rs9506352

0.34

T

0.300

278:138, 242:128

0.674

 

rs9579648

0.15

C

0.317

68:350, 52:320

0.371

 

rs9579649

0.07

T

0.330

28:388, 24:348

0.875

 

rs9315051

0.08

C

1.000

33:385, 26:346

0.629

 

rs4420371

0.25

C

0.842

107:311, 93:277

0.882

 

rs4466940

0.20

T

0.295

85:329, 60:256

0.604

 

rs9578200

0.17

T

0.014

352:66, 307:65

0.525

 

rs9285076

0.22

T

0.133

326:92, 289:83

0.919

 

rs9670198

0.04

A

0.168

401:15, 329:13

0.887

 

rs4319601

0.41

T

0.064

241:163, 209:143

0.938

 

rs4769063

0.13

T

1.000

365:51, 322:50

0.621

 

rs4238139

0.28

C

0.028

117:301, 99:265

0.805

ALOX5 (10)

rs3824612

0.38

T

0.263

273:145, 220:152

0.074

 

rs3780894

0.17

C

0.789

85:333, 52:320

0.019

 

rs7099684

0.19

A

0.456

82:332, 65:301

0.466

 

rs7919239

0.23

A

0.392

101:313, 79:293

0.293

 

rs2115819

0.47

C

0.414

195:219, 152:180

0.720

 

rs11239523

0.16

C

0.831

71:345, 55:317

0.383

 

rs4948672

0.46

C

0.512

203:215, 161:211

0.137

 

rs12264801

0.45

T

0.028

230:188, 202:168

0.904

 

rs3780901

0.33

C

0.440

143:271, 116:250

0.400

 

rs2279435

0.43

C

0.707

187:231, 156:216

0.428

 

rs1565096

0.23

C

0.094

323:95, 283:89

0.691

 

rs1487562

0.21

T

0.381

97:321, 69:301

0.117

 

rs2291427

0.30

T

0.870

298:120, 257:115

0.498

 

rs7393696

0.38

A

0.394

256:154, 207:135

0.591

 

rs7089063

0.24

A

0.478

112:304, 61:233

0.059

CYSLTR2 (13)

rs2406939

0.36

C

0.948

152:266, 130:242

0.678

 

rs11617224

0.11

C

1.000

375:43, 329:41

0.719

 

rs6420296

0.08

C

1.000

389:29, 337:33

0.303

 

rs7335898

0.06

G

0.790

28:390, 18:336

0.345

 

rs9285169

0.09

T

0.136

43:373, 26:334

0.129

 

rs9595961

0.48

C

0.994

203:215, 175:195

0.722

 

rs17072059

0.04

T

0.784

407:11, 353:17

0.137

 

rs7330127

0.44

A

1.000

189:229, 155:207

0.501

 

rs2407249

0.21

C

0.129

88:330, 74:298

0.687

 

rs9568087

0.29

A

0.315

299:117, 254:108

0.600

 

rs12184704

0.07

C

0.057

33:385, 21:339

0.259

CYSLTR1 (X)*

rs321090

0.23

C

0.605

247:60, 207:81

0.014

 

rs321007

0.30

C

0.916

224:84, 192:96

0.107

 

rs321006

0.13

T

0.423

42:266, 37:252

0.764

LTC4S (5)

rs730012

0.29

C

0.403

126:292, 103:269

0.448

 

rs2291418

0.04

T

0.316

399:15, 347:19

0.284

 

rs166624

0.17

A

1.000

77:341, 56:316

0.207

  1. HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency.
  2. *Hardy-Weinberg and association tests were specifically calculated for the X chromosome using the method implemented in Haploview 3.32.
  3. **Number of allele A observed in cases : number of allele B observed in cases, number of allele A observed in controls : number of allele B observed in controls.
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BMC Medical Genetics

ISSN: 1471-2350

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