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Table 1 Association between single nucleotide polymorphisms in leukotriene pathway candidate genes and chronic rhinosinusitis.

From: Influence of leukotriene gene polymorphisms on chronic rhinosinusitis

Gene (chr) SNPs MAF Minor allele HWE p value Case, Control Ratios** p value
ALOX5AP (13) rs12430915 0.08 C 0.200 38:378, 26:346 0.271
  rs4769870 0.16 T 0.080 353:61, 269:61 0.170
  rs4076128 0.30 C 0.439 290:124, 255:111 0.909
  rs11616333 0.05 G 0.558 22:396, 19:353 0.922
  rs4769055 0.33 A 0.187 143:275, 120:252 0.561
  rs9578196 0.10 T 0.408 380:38, 326:42 0.283
  rs4293222 0.37 C 0.930 161:257, 134:236 0.505
  rs12429692 0.26 T 1.000 118:300, 88:284 0.144
  rs10162089 0.49 T 0.828 217:197, 184:186 0.453
  rs4254165 0.28 C 0.928 302:114, 264:108 0.612
  rs4356336 0.42 C 1.000 242:176, 208:154 0.902
  rs17612127 0.08 T 0.847 40:376, 21:343 0.046
  rs9506352 0.34 T 0.300 278:138, 242:128 0.674
  rs9579648 0.15 C 0.317 68:350, 52:320 0.371
  rs9579649 0.07 T 0.330 28:388, 24:348 0.875
  rs9315051 0.08 C 1.000 33:385, 26:346 0.629
  rs4420371 0.25 C 0.842 107:311, 93:277 0.882
  rs4466940 0.20 T 0.295 85:329, 60:256 0.604
  rs9578200 0.17 T 0.014 352:66, 307:65 0.525
  rs9285076 0.22 T 0.133 326:92, 289:83 0.919
  rs9670198 0.04 A 0.168 401:15, 329:13 0.887
  rs4319601 0.41 T 0.064 241:163, 209:143 0.938
  rs4769063 0.13 T 1.000 365:51, 322:50 0.621
  rs4238139 0.28 C 0.028 117:301, 99:265 0.805
ALOX5 (10) rs3824612 0.38 T 0.263 273:145, 220:152 0.074
  rs3780894 0.17 C 0.789 85:333, 52:320 0.019
  rs7099684 0.19 A 0.456 82:332, 65:301 0.466
  rs7919239 0.23 A 0.392 101:313, 79:293 0.293
  rs2115819 0.47 C 0.414 195:219, 152:180 0.720
  rs11239523 0.16 C 0.831 71:345, 55:317 0.383
  rs4948672 0.46 C 0.512 203:215, 161:211 0.137
  rs12264801 0.45 T 0.028 230:188, 202:168 0.904
  rs3780901 0.33 C 0.440 143:271, 116:250 0.400
  rs2279435 0.43 C 0.707 187:231, 156:216 0.428
  rs1565096 0.23 C 0.094 323:95, 283:89 0.691
  rs1487562 0.21 T 0.381 97:321, 69:301 0.117
  rs2291427 0.30 T 0.870 298:120, 257:115 0.498
  rs7393696 0.38 A 0.394 256:154, 207:135 0.591
  rs7089063 0.24 A 0.478 112:304, 61:233 0.059
CYSLTR2 (13) rs2406939 0.36 C 0.948 152:266, 130:242 0.678
  rs11617224 0.11 C 1.000 375:43, 329:41 0.719
  rs6420296 0.08 C 1.000 389:29, 337:33 0.303
  rs7335898 0.06 G 0.790 28:390, 18:336 0.345
  rs9285169 0.09 T 0.136 43:373, 26:334 0.129
  rs9595961 0.48 C 0.994 203:215, 175:195 0.722
  rs17072059 0.04 T 0.784 407:11, 353:17 0.137
  rs7330127 0.44 A 1.000 189:229, 155:207 0.501
  rs2407249 0.21 C 0.129 88:330, 74:298 0.687
  rs9568087 0.29 A 0.315 299:117, 254:108 0.600
  rs12184704 0.07 C 0.057 33:385, 21:339 0.259
CYSLTR1 (X)* rs321090 0.23 C 0.605 247:60, 207:81 0.014
  rs321007 0.30 C 0.916 224:84, 192:96 0.107
  rs321006 0.13 T 0.423 42:266, 37:252 0.764
LTC4S (5) rs730012 0.29 C 0.403 126:292, 103:269 0.448
  rs2291418 0.04 T 0.316 399:15, 347:19 0.284
  rs166624 0.17 A 1.000 77:341, 56:316 0.207
  1. HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency.
  2. *Hardy-Weinberg and association tests were specifically calculated for the X chromosome using the method implemented in Haploview 3.32.
  3. **Number of allele A observed in cases : number of allele B observed in cases, number of allele A observed in controls : number of allele B observed in controls.