Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission

Table 5 T allele frequencies of the TGFβ1 -508 T>C SNP (rs1800469) as found by this study (*) and other studies.

T Allele Frequency		Population Studied	Reference
Disease	Control
-	0.31	Healthy female twins	Grainger et al. (1999) ^[49]
0.33	0.31	Prostate cancer	Ewart-Toland et al. (2004) ^[67]
Belgian: 0.32 Canadian: 0.32	Belgian: 0.31 Canadian: 0.32	Abdominal aortic aneurysms	Ogata et al. (2005) ^[68]
All IBD: 0.34 Crohn's disease: 0.42 Ulcerative colitis: 0.35	0.26	Inflammatory bowel disease (IBD) – Crohn's disease and ulcerative colitis	Schulte et al. (2001) ^[69]
0.28 ^#	0.29 ^#	Multiple sclerosis	Green et al. (2001) ^[50]
0.29	0.27	Multiple sclerosis	Weinshenker et al. (2001) ^[51]
0.33	0.30	Multiple sclerosis*	This study

^# Green et al [50] investigated the frequencies of TGFβ1 haplotypes comprising of five biallelic polymorphisms, including two in the promoter region (one being the -508 T>C) and three in coding regions. Three haplotypes: GTCGC; GTTGC; and GTCGC, each containing the T allele (bold) at position -508 had frequencies of 0.24, 0.025 and 0.018 (0.28) in the controls and 0.25, 0.019, and 0.018 (0.29) in the MS individuals with no significant difference between the two groups.

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