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Table 5 T allele frequencies of the TGFβ1 -508 T>C SNP (rs1800469) as found by this study (*) and other studies.

From: Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission

T Allele Frequency Population Studied Reference
Disease Control   
- 0.31 Healthy female twins Grainger et al. (1999) [49]
0.33 0.31 Prostate cancer Ewart-Toland et al. (2004) [67]
Belgian: 0.32
Canadian: 0.32
Belgian: 0.31
Canadian: 0.32
Abdominal aortic aneurysms Ogata et al. (2005) [68]
All IBD: 0.34
Crohn's disease: 0.42
Ulcerative colitis: 0.35
0.26 Inflammatory bowel disease (IBD) – Crohn's disease and ulcerative colitis Schulte et al. (2001) [69]
0.28 # 0.29 # Multiple sclerosis Green et al. (2001) [50]
0.29 0.27 Multiple sclerosis Weinshenker et al. (2001) [51]
0.33 0.30 Multiple sclerosis* This study
  1. # Green et al [50] investigated the frequencies of TGFβ1 haplotypes comprising of five biallelic polymorphisms, including two in the promoter region (one being the -508 T>C) and three in coding regions. Three haplotypes: GTCGC; GTTGC; and GTCGC, each containing the T allele (bold) at position -508 had frequencies of 0.24, 0.025 and 0.018 (0.28) in the controls and 0.25, 0.019, and 0.018 (0.29) in the MS individuals with no significant difference between the two groups.