Skip to main content

Table 6 Marginal means for intravenous glucose tolerance measures

From: Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis

SNP

 

Utah Caucasian Family samples

Arkansas Caucasian population

rs10847

 

CC

CT

TT

p-value

CC

CT

TT

p-value

 

n

68

47

10

 

124

85

21

 
 

S I

5.66 (4.29,7.48)

6.14 (4.64,8.11)

7.75 (1.84,32.64)

0.84

4.85 (4.11, 5.71)

5.45 (4.47, 6.63)

5.42 (3.58, 8.18)

0.64

 

AIRg

116 (93,145)

152 (122,190)

249 (81,757)

0.09

2370 (2082,2694))

2142 (1830,2502)

1890 (1380,2580)

0.32

 

DI

0.99 (0.59,1.66)

1.29 (0.77,2.16)

1.55 (0.42,5.68)

0.5

1152 (969,1371)

1173 (951,1447)

1111 (716,1725)

0.37

rs188970

 

CC

CT

TT

p-value

CC

CT

TT

p-value

 

n

48

51

23

 

87

103

32

 
 

S I

5.29 (4.11,6.81)

6.40 (4.83,8.46)

6.45 (4.27,9.73)

0.49

5.68 (5.07, 6.37)

5.40 (4.85, 6.00)

5.70 (4.68, 6.93)

0.11

 

AIRg

200 (163,246)

141 (113,177)

115 (82,159)

0.005

2388 (2046,2784)

2082 (1806,2400)

2664 (2052, 3468)

0.18

 

DI

1.25 (0.76,2.06)

1.13 (0.65,1.97)

1.07 (0.47,2.42)

0.91

1356 (1170,1573)

1122 (979,1287)

1520 (1180,1958)

0.37

rs2134688

 

TT

TC+CC

p-value

TT

TC+CC

p-value

 

n

96

26

 

193

36

 
 

S I

6.62 (6.21,8.41)

5.80 (3.56,9.45)

0.86

5.48 (5.05,6.37)

5.38 (4.43, 6.52)

0.86

 

AIR g

164 (134, 200)

132 (88, 197)

0.31

2244 (2022,2490)

2280 (1788,2910)

0.66

 

DI

1.33 (0.91,1.95)

1.07 (0.59,1.93)

0.5

1132 (987,1299)

1201 (867,1633)

0.94

rs11204735

 

GG

GA

AA

p-value

GG

GA

AA

p-value

 

n

34

53

31

 

66

115

48

 
 

S I

5.49 (3.90,7.72)

6.28 (4.70,8.39)

4.92 (3.61,6.71)

0.46

5.60 (4.88, 6.45)

5.22 (4.70, 5.78)

5.52 (4.68, 6.52)

0.66

 

AIRg

117 (89,152)

150 (119,188)

216 (169,277)

0.002

2370 (1986,2832)

2220 (1944,2538)

2190 (1776,2700)

0.8

 

DI

0.71 (0.38,132)

1.36 (0.81,230)

1.36 (0.78,2.38)

0.14

1328 (1112,1587)

1157 (1012,1322)

1209 (980,1492)

0.46

  1. Marginal means are shown after adjustment for age, gender and BMI; significance is based on a general linear model and p values are shown without correction for multiple testing. AIRg in the Utah Caucasian study is from the mean 2–10 min post challenge insulin excursion in pmol/l; for Arkansas Caucasian study, the AIRg is taken from MinMod Millenium output and is the area under the curve from 0 to 10 min, converted to pmol/l. All means are transformed back to the linear scale from Ln-transformed values; 95% confidence intervals are provided in parenthesis. SI, insulin sensitivity index from MinMod in (pmol/l) min-1; AIRg, acute 2–10 min insulin response to intravenous glucose bolus, in pmol/l (UT sample) or pmol-min/l (AR sample); DI, Disposition index (SI × AIRg) has no units. Values from the Utah sample are × 10-2. Note that the MinMod Millenium program calculates disposition index using the area under curve for AIRg and without the decimal places for SI (10-5 (pmol/l) min-1. Because calculations in the Utah population used mean 2 min – 10 min insulin to calculate AIRg and calculated SI × AIRg values were calculated using the legacy MinMod program and Arkansas samples using the MinMod Millenium program, the values between populations are not directly comparable.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us