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Table 6 Marginal means for intravenous glucose tolerance measures

From: Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis

SNP   Utah Caucasian Family samples Arkansas Caucasian population
rs10847   CC CT TT p-value CC CT TT p-value
  n 68 47 10   124 85 21  
  S I 5.66 (4.29,7.48) 6.14 (4.64,8.11) 7.75 (1.84,32.64) 0.84 4.85 (4.11, 5.71) 5.45 (4.47, 6.63) 5.42 (3.58, 8.18) 0.64
  AIRg 116 (93,145) 152 (122,190) 249 (81,757) 0.09 2370 (2082,2694)) 2142 (1830,2502) 1890 (1380,2580) 0.32
  DI 0.99 (0.59,1.66) 1.29 (0.77,2.16) 1.55 (0.42,5.68) 0.5 1152 (969,1371) 1173 (951,1447) 1111 (716,1725) 0.37
rs188970   CC CT TT p-value CC CT TT p-value
  n 48 51 23   87 103 32  
  S I 5.29 (4.11,6.81) 6.40 (4.83,8.46) 6.45 (4.27,9.73) 0.49 5.68 (5.07, 6.37) 5.40 (4.85, 6.00) 5.70 (4.68, 6.93) 0.11
  AIRg 200 (163,246) 141 (113,177) 115 (82,159) 0.005 2388 (2046,2784) 2082 (1806,2400) 2664 (2052, 3468) 0.18
  DI 1.25 (0.76,2.06) 1.13 (0.65,1.97) 1.07 (0.47,2.42) 0.91 1356 (1170,1573) 1122 (979,1287) 1520 (1180,1958) 0.37
rs2134688   TT TC+CC p-value TT TC+CC p-value
  n 96 26   193 36  
  S I 6.62 (6.21,8.41) 5.80 (3.56,9.45) 0.86 5.48 (5.05,6.37) 5.38 (4.43, 6.52) 0.86
  AIR g 164 (134, 200) 132 (88, 197) 0.31 2244 (2022,2490) 2280 (1788,2910) 0.66
  DI 1.33 (0.91,1.95) 1.07 (0.59,1.93) 0.5 1132 (987,1299) 1201 (867,1633) 0.94
rs11204735   GG GA AA p-value GG GA AA p-value
  n 34 53 31   66 115 48  
  S I 5.49 (3.90,7.72) 6.28 (4.70,8.39) 4.92 (3.61,6.71) 0.46 5.60 (4.88, 6.45) 5.22 (4.70, 5.78) 5.52 (4.68, 6.52) 0.66
  AIRg 117 (89,152) 150 (119,188) 216 (169,277) 0.002 2370 (1986,2832) 2220 (1944,2538) 2190 (1776,2700) 0.8
  DI 0.71 (0.38,132) 1.36 (0.81,230) 1.36 (0.78,2.38) 0.14 1328 (1112,1587) 1157 (1012,1322) 1209 (980,1492) 0.46
  1. Marginal means are shown after adjustment for age, gender and BMI; significance is based on a general linear model and p values are shown without correction for multiple testing. AIRg in the Utah Caucasian study is from the mean 2–10 min post challenge insulin excursion in pmol/l; for Arkansas Caucasian study, the AIRg is taken from MinMod Millenium output and is the area under the curve from 0 to 10 min, converted to pmol/l. All means are transformed back to the linear scale from Ln-transformed values; 95% confidence intervals are provided in parenthesis. SI, insulin sensitivity index from MinMod in (pmol/l) min-1; AIRg, acute 2–10 min insulin response to intravenous glucose bolus, in pmol/l (UT sample) or pmol-min/l (AR sample); DI, Disposition index (SI × AIRg) has no units. Values from the Utah sample are × 10-2. Note that the MinMod Millenium program calculates disposition index using the area under curve for AIRg and without the decimal places for SI (10-5 (pmol/l) min-1. Because calculations in the Utah population used mean 2 min – 10 min insulin to calculate AIRg and calculated SI × AIRg values were calculated using the legacy MinMod program and Arkansas samples using the MinMod Millenium program, the values between populations are not directly comparable.