Table 2 Evolutionary conservation of the variant TSC2 amino acids. Inter-species conservation of the TSC2 S132, F143, A196, C244, Y598 I820, T993, L1511 and R1772 amino acids is shown.
Family 1 | |||
|---|---|---|---|
I820 | R1772 | ||
human | PDII I KALP | GQRK R LISS | |
mouse | PDII I KAL | GQRK R LISS | |
rat | PDII I KAL | GQRK R LISS | |
pufferfish | PDIM I KLL | GQRK R LVST | |
fruitfly | PEALMRKLP | no homology | |
Family 2 | |||
T993 | L1511 | ||
human | SRIQ T SLTS | SVQL L DQI | |
mouse | SRIQ T SLTS | SVQL L DQI | |
rat | SRIQ T SLTS | SVQL L DQI | |
pufferfish | RRMH T STTT | AVKV L DQM | |
fruitfly | no homology | AVSLIDLVP | |
Family 3 | |||
A196 | Y598 | ||
human | DEYI A RM V | IQLH Y KHSY | |
mouse | DEYI A SM V | IQLH Y KHGY | |
rat | DEYI A PM V | IQLH Y KHGY | |
pufferfish | DQNV A SM V | LQLH Y KNKY | |
fruitfly | DKDILVGIV | LELH Y ERPK | |
Family 4 | |||
S132 | F143 | C244 | |
human | KDYP S NED | RLEV F KALT | IVTL C RTIN |
mouse | KDYP S NED | RLEV F KALT | IITL C RTIN |
rat | KDYP S NED | RLEV F KALT | IITL C RTVN |
pufferfish | RDYQPCNED | RLEV F KALT | IITL C RTVN |
fruitfly | IQNHEARED | LLELLDTLT | ITTL C RTVN |