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Table 1 Characteristics of phenotypes studied*

From: Framingham Heart Study genome-wide association: results for pulmonary function measures

    Eligible exam cycles    
Phenotype Na Description Offspring Cohort Adjustmentb Heritability
ppfev1 1217 Percent predicted FEV1 for latest exam 7, 6, 5, 3 19, 17, 13 Predicted defined by age, age2, height, % predicted adjusted for current or former smoking, pack-years, and BMI 0.36
ppfvc 1217 Percent predicted FVC for latest exam 7, 6, 5, 3 19, 17, 13 Same as ppfev1 0.45
ppratio 1217 Percent predicted FEV1/FVC for latest exam 7, 6, 5, 3 19, 17, 13 Same as ppfev1 0.29
ppfef 1212 Percent predicted FEF25–75 for latest exam 7, 6, 5, 3 19, 17, 13 Same as ppfev1 0.40
ppfefrat 1212 Percent predicted FEF25–75/FVC for latest exam 7, 6, 5, 3 19, 17, 13 Same as ppfev1 0.41
meanfev1 1222 Mean FEV1 from two exams 3 and 5 5 or 6 and 13 age, age2, BMI, height, current or former smoking, and pack-years 0.35
meanfvc 1222 Mean FVC from two exams 3 and 5 5 or 6 and 13 Same as meanfev1 0.51
meanratio 1222 Mean FEV1/FVC from two exams 3 and 5 5 or 6 and 13 Same as meanfev1 0.25
fev1slope 1097 Longitudinal slope of FEV1 7, 6, 5, 3 19, 17, 13 age, age2, height, height2, pack-years at first exam, interim pack-years, and sustained smoking 0.10
fefslope 1059 Longitudinal slope of FEF25–75 7, 6, 5, 3 19, 17, 13 Same as fev1slope 0.20
  1. *Results for additional longitudinal slope phenotypes, residual from predicted phenotypes, phenotypes created from spirometry at a single exam, and phenotypes limited to smokers reporting 10 or more pack-years are available at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007
  2. a) sample size with phenotype out of 1345 with GWA genotyping
  3. b) adjustment performed in four separate regression models by sex and Original or Offspring cohort