Table 1 Characteristics of phenotypes studied*
From: Framingham Heart Study genome-wide association: results for pulmonary function measures
| Â | Â | Â | Eligible exam cycles | Â | Â | Â |
|---|---|---|---|---|---|---|
Phenotype | Na | Description | Offspring | Cohort | Adjustmentb | Heritability |
ppfev1 | 1217 | Percent predicted FEV1 for latest exam | 7, 6, 5, 3 | 19, 17, 13 | Predicted defined by age, age2, height, % predicted adjusted for current or former smoking, pack-years, and BMI | 0.36 |
ppfvc | 1217 | Percent predicted FVC for latest exam | 7, 6, 5, 3 | 19, 17, 13 | Same as ppfev1 | 0.45 |
ppratio | 1217 | Percent predicted FEV1/FVC for latest exam | 7, 6, 5, 3 | 19, 17, 13 | Same as ppfev1 | 0.29 |
ppfef | 1212 | Percent predicted FEF25–75 for latest exam | 7, 6, 5, 3 | 19, 17, 13 | Same as ppfev1 | 0.40 |
ppfefrat | 1212 | Percent predicted FEF25–75/FVC for latest exam | 7, 6, 5, 3 | 19, 17, 13 | Same as ppfev1 | 0.41 |
meanfev1 | 1222 | Mean FEV1 from two exams | 3 and 5 | 5 or 6 and 13 | age, age2, BMI, height, current or former smoking, and pack-years | 0.35 |
meanfvc | 1222 | Mean FVC from two exams | 3 and 5 | 5 or 6 and 13 | Same as meanfev1 | 0.51 |
meanratio | 1222 | Mean FEV1/FVC from two exams | 3 and 5 | 5 or 6 and 13 | Same as meanfev1 | 0.25 |
fev1slope | 1097 | Longitudinal slope of FEV1 | 7, 6, 5, 3 | 19, 17, 13 | age, age2, height, height2, pack-years at first exam, interim pack-years, and sustained smoking | 0.10 |
fefslope | 1059 | Longitudinal slope of FEF25–75 | 7, 6, 5, 3 | 19, 17, 13 | Same as fev1slope | 0.20 |