Table 2 Cancer Phenotypes for FHS 100K Project: Results of Association Analyses*
From: A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study
2a. GEE results ranked by p-value | |||||
|---|---|---|---|---|---|
SNP | Chr | Physical Position | GEE p-value | FBAT p-value | Gene region (within 60 kb) |
BREAST CANCER | |||||
rs2075555 | 17 | 45,629,290 | 8.3 × 10 -8 | 0.157 | COL1A1 |
rs6556756 | 5 | 163,821,858 | 5.0 × 10 -7 | 0.114 |  |
rs1154865 | 12 | 72,276,104 | 6.6 × 10 -7 | 0.052 |  |
rs1978503 | 18 | 51,815,280 | 9.66 × 10 -7 | 0.287 |  |
rs1926657 | 13 | 94,672,957 | 1.9 × 10 -6 | 0.072 | ABCC4 |
rs10263639 | 7 | 66,503,417 | 2.7 × 10 -6 | 0.590 |  |
rs10490113 | 2 | 59,410,998 | 4.7 × 10 -6 | 0.077 |  |
rs458685 | 21 | 30,099,382 | 6.0 × 10 -6 | 0.064 | GRIK1 |
rs1876206 | 15 | 46,687,878 | 6.0 × 10 -6 | 0.742 | FBN1 |
rs9314033 | 5 | 163,822,784 | 1.2 × 10 -5 | 0.058 |  |
rs10486490 | 7 | 25,846,789 | 1.3 × 10 -5 | 0.245 |  |
rs9325024 | 5 | 146,185,979 | 1.7 × 10 -5 | 0.112 | PPP2R2B |
rs1294255 | 1 | 229,808,093 | 1.9 × 10 -5 | 0.470 |  |
rs10513754 | 3 | 178,681,862 | 2.8 × 10 -5 | 0.189 |  |
rs10501093 | 11 | 27,946,695 | 3.0 × 10 -5 | 0.066 | KIF18A |
PROSTATE CANCER | |||||
rs9311171 | 3 | 37,971,481 | 1.8 × 10 -6 | 0.392 | CTDSPL |
rs1529276 | 13 | 102,726,008 | 1.8 × 10 -6 | 0.071 |  |
rs10498792 | 6 | 51,774,590 | 3.0 × 10 -6 | 0.285 | PKHD1 |
rs4466137 | 5 | 83,021,495 | 3.1 × 10 -6 | 0.305 | HAPLN1 |
rs345013 | 3 | 146,656,486 | 5.1 × 10 -6 | 0.002 |  |
rs10505137 | 8 | 111,210,785 | 1.3 × 10 -5 | 0.002 |  |
rs1873038 | 3 | 175,020,343 | 1.8 × 10 -5 | 0.317 | NLGN1 |
rs8019932 | 14 | 29,676,177 | 1.9 × 10 -5 | 0.019 |  |
rs344985 | 3 | 146,619,475 | 2.1 × 10 -5 | 0.002 |  |
rs1920676 | 11 | 15,789,323 | 2.2 × 10 -5 | 0.196 |  |
rs10511206 | 10 | 127,209,365 | 2.4 × 10 -5 | 0.028 |  |
rs1037569 | 5 | 119,954,204 | 2.8 × 10 -5 | 0.165 |  |
rs2109312 | 2 | 128,292,061 | 3.0 × 10 -5 | 0.786 | WDR33 |
rs1352416 | 3 | 174,963,409 | 3.4 × 10 -5 | 0.201 | NLGN1 |
rs1440714 | 11 | 15,,790,399 | 3.7 × 10 -5 | 0.223 |  |
2b. FBAT results ranked by p-value | |||||
SNP | Chr | Physical Position | GEE p-value | FBAT p-value | Gene Region (within 60 kb) |
BREAST CANCER | |||||
rs7711990 | 5 | 180,307,504 | 0.010 | 8.4 × 10 -5 |  |
rs1451125 | 4 | 137,449,995 | 0.008 | 9.5 × 10 -5 |  |
rs4266352 | 4 | 109,823,951 | 0.001 | 1.2 × 10 -4 |  |
rs6720918 | 2 | 122,873,276 | 0.027 | 1.9 × 10 -4 |  |
rs6101183 | 20 | 59,025,355 | 0.132 | 2.0 × 10 -4 |  |
rs9307064 | 4 | 90,503,827 | 0.159 | 2.2 × 10 -4 |  |
rs10512287 | 9 | 101,538,523 | 0.807 | 2.3 × 10 -4 | GRIN3A |
rs7190881 | 16 | 7,368,424 | 0.475 | 2.9 × 10 -4 |  |
rs2224402 | 1 | 229,359,076 | 0.418 | 3.1 × 10 -4 | C1orf57 |
rs10516690 | 4 | 84,822,792 | 0.954 | 3.7 × 10 -4 |  |
rs10487920 | 7 | 145,895,727 | 0.085 | 3.9 × 10 -4 | CNTNAP2 |
rs6479347 | 9 | 91,348,121 | 0.017 | 4.5 × 10 -4 |  |
rs1924587 | 13 | 96,195,380 | 0.020 | 4.6 × 10 -4 | HS6ST3 |
rs2059273 | 16 | 5,991,144 | 0.005 | 4.9 × 10 -4 | A2BP1 |
rs2822669 | 21 | 14,752,449 | 0.029 | 5.7 × 10 -4 | SAMSN1 |
PROSTATE CANCER | |||||
rs657057 | 6 | 56,402,241 | 0.109 | 3.4 × 10 -5 | DST |
rs6691482 | 1 | 170,274,521 | 0.007 | 4.0 × 10 -5 | SLC9A11 |
rs4378061 | 9 | 10,930,127 | 0.633 | 6.6 × 10 -5 |  |
rs2056387 | 1 | 234,250,153 | 0.159 | 1.1 × 10 -4 | RYR2 |
rs2274626 | 1 | 176,253,589 | 0.005 | 1.4 × 10 -4 | NPHS2 |
rs181247 | 17 | 53,562,730 | 0.552 | 3.2 × 10 -4 | OR4D1|OR4D2 |
rs7827348 | 8 | 3,020,222 | 0.054 | 3.6 × 10 -4 |  |
rs255561 | 5 | 82,386,566 | 0.040 | 3.9 × 10 -4 | XRCC4 |
rs1504858 | 4 | 137,063,555 | 0.010 | 3.9 × 10 -4 |  |
rs954709 | 4 | 167,317,424 | 0.049 | 4.2 × 10 -4 |  |
rs2179443 | 20 | 37,450,516 | 0.057 | 4.4 × 10 -4 |  |
rs35239 | 5 | 68,064,834 | 0.657 | 4.6 × 10 -4 |  |
rs477516 | 8 | 16,758,362 | 0.057 | 5.1 × 10 -4 |  |
rs595725 | 1 | 28,993,331 | 0.239 | 5.3 × 10 -4 | OPRD1 |
rs10515322 | 5 | 101,539,543 | 0.051 | 5.4 × 10 -4 | SLCO4C1 |