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Table 1 Cancer Phenotypes for the Framingham Heart Study 100K Analyses

From: A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study

Phenotype*

Traits

Number of participants

Events

Adjustment (database phenotype variable name)

All Cancer* (excluding non-melanoma skin cancer)

2

1335

250

Cohort- and sex-specific

1. age at study entry (allcancer1)

2. multivariable adjusted for age, body mass index, and cigarette smoking at study entry (allcancer2)

Breast Cancer (women)

2

723

58

Cohort-specific

1. age at study entry (breastcancer1)

2. multivariable adjusted for age, parity, and body mass index at study entry (breastcancer2)

Prostate Cancer (men)

1

617

59

Cohort-specific

1. age at study entry (prostatecancer1)

  1. Residuals from these models were used as traits to test for association with SNP genotypes. All residuals created using Cox Proportional Hazards regression. Cancers ascertained through December 31, 2005
  2. *All SNP associations for all phenotypes in the table including all cancer are available on the web http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007
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BMC Medical Genetics

ISSN: 1471-2350

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