BMC Medical Genetics

Table 2 Additive Genetic Model – ordered by GEE (2a) and FBAT (2b) p-value Results

From: Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes

Phenotype	SNP	Chromosome	Position	GEE P value	FBAT P value	Gene
2a. Results ordered by GEE p-value results
AF	rs958546	13	45,731,718	4.78E-06	0.104
Major CVD	rs499818	6	13,440,446	6.64E-06	0.17
AF	rs4776472	15	67,793,927	7.87E-06	0.042
HF	rs740363	10	118,565,596	8.82E-06	0.065	KIAA1598
AF	rs10501920	11	98,998,383	9.40E-06	0.448	CNTN5
Major CHD	rs2549513	16	78,108,228	9.65E-06	0.106
AF	rs10507539	13	45,732,707	1.05E-05	0.02
Major CVD	rs1512411	6	13,439,076	1.55E-05	0.366	PHACTR1, TBC1D7
Major CVD	rs10511701	9	22,102,599	1.67E-05	0.132
Major CVD	rs1556516	9	22,090,176	1.86E-05	0.071
Major CVD	rs1537371	9	22,089,568	1.87E-05	0.068
Major CHD	rs10497726	2	192,876,826	1.98E-05	0.046	TMEFF2
Major CHD	rs2962994	15	55,129,991	1.98E-05	0.279	TCF12
Major CHD	rs997651	17	61,344,845	2.28E-05	0.547	MGC33887
Major CVD	rs2148079	13	109,989,414	2.33E-05	0.026	RAB20
AF	rs10501918	11	98,971,412	2.40E-05	0.093	CNTN5
HF	rs10511633	9	17,151,527	2.59E-05	0.044	C9orf39
Major CHD	rs7836535	8	96,774,748	2.63E-05	0.003
Major CHD	rs1820996	15	55,120,501	2.83E-05	0.218	TCF12
Major CHD	rs213168	15	55,028,949	3.09E-05	0.278	TCF12
Major CHD	rs997652	17	61,344,827	3.22E-05	0.613	MGC33887
AF	rs4590838	11	97,372,875	4.03E-05	0.248
Major CHD	rs10516882	4	92,265,754	4.33E-05	0.858
Major CVD	rs1742083	14	90,256,423	5.23E-05	0.138	TTC7B
Major CVD	rs507369	6	13,440,039	6.23E-05	0.137	PHACTR1, TBC1D7
2b. Results Ordered by FBAT
Major CHD	rs10505879	12	22,539,123	0.058	3.06E-05	KIAA0528
Major CVD	rs39312	7	116,548,736	0.138	4.37E-05	WNT2
AF	rs10511311	3	113,538,529	0.003	4.45E-05	CD200
AF	rs1427828	12	88,264,967	0.018	4.58E-05	DUSP6
HF	rs10515869	5	163,444,804	0.029	4.72E-05
AF	rs1751382	14	67,762,403	0.138	5.14E-05	RAD51L1
AF	rs1314913	14	67,769,347	0.126	5.53E-05	RAD51L1
AF	rs262467	6	120,497,469	0.117	6.39E-05
AF	rs412253	4	31,119,019	0.086	6.55E-05
Major CVD	rs39317	7	116,560,255	0.219	6.72E-05	WNT2, ASZ1
Major CVD	rs9886209	7	116,599,175	0.594	6.95E-05	ASZ1
Major CVD	rs10493900	1	98,357,234	0.801	7.10E-05
AF	rs1298340	14	67,747,245	0.275	7.40E-05	RAD51L1
Major CVD	rs2452503	10	60,686,639	0.384	9.94E-05	FAM13C1
AF	rs324735	4	77,062,193	0.018	9.98E-05
Major CHD	rs580069	11	121,794,555	0.074	1.24E-04
AF	rs1604355	1	187,190,664	0.294	1.29E-04	FAM5C
Major CHD	rs559453	11	121,794,482	0.073	1.32E-04
Major CHD	rs951442	15	31,705,234	0.003	1.35E-04	RYR3
HF	rs1176486	10	132,315,529	0.165	1.49E-04
AF	rs2421954	2	63,665,926	0.003	1.51E-04	LOC51057
HF	rs9313999	5	163,444,569	0.015	1.55E-04
AF	rs7676376	4	158,199,764	0.282	1.72E-04	PDGFC
Major CHD	rs10501127	11	33,698,233	0.251	1.78E-04	CD59
AF	rs1163397	3	110,400,929	0.002	1.78E-04

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