Skip to main content

Table 2 Twenty five lowest p-values from GEE and FBAT models and LOD scores > 2 for 100K SNPs and FHS diabetes-related quantitative traits

From: Genome-wide association with diabetes-related traits in the Framingham Heart Study

No.

Trait

SNP

Chr

Physical position

GEE or Cox p-value

FBAT p-value

Known Genes

 

2a. Ordered by GEE p-value

1

tFPG

rs2722425

8

40603396

0.00000002

0.0047

ZMAT4

 

2

Incident DM

rs10497721

2

192739868

0.0000007

0.0346

TMEFF2

 

3

Fasting Insulin

rs2877832

14

26870017

0.000002

0.0770

  

4

HOMA-IR

rs2877832

14

26870017

0.000003

0.0918

  

5

tFPG

rs10510634

3

30321972

0.000005

0.0516

  

6

FPG

rs180730

4

122159395

0.000005

0.0374

PRDM5

 

7

tFPG

rs180730

4

122159395

0.000006

0.0252

PRDM5

 

8

tFPG

rs7731657

5

129971218

0.000007

0.0015

  

9

HbA1c

rs10486607

7

28957729

0.000008

0.0440

CPVL

 

10

ISI_0-120

rs2066219

13

68428665

0.000009

0.0245

  

11

FPG

rs2722425

8

40603396

0.000009

0.0998

ZMAT4

 

12

Incident DM

rs2195499

2

41778050

0.000011

0.3860

  

13

Incident DM

rs830604

3

71673037

0.000014

0.5914

FOXP1

 

14

FPG

rs2377689

2

106924358

0.000017

0.0015

ST6GAL2

 

15

Incident DM

rs931567

3

31410581

0.000018

0.0095

  

16

FPG

rs10494331

1

156395176

0.000019

0.0369

APCS

 

17

tFPG

rs7147624

14

64935378

0.000019

0.0201

FUT8

 

18

tFPG

rs931567

3

31410581

0.000019

0.0189

  

19

Incident DM

rs10511182

3

102255525

0.000020

0.0510

  

20

FPG

rs337112

5

122556671

0.000022

0.0148

  

21

ISI_0-120

rs9319109

13

84510270

0.000025

0.0048

  

22

HOMA-IR

rs1927384

13

101943751

0.000026

0.0059

  

23

ISI_0-120

rs7139897

13

107879625

0.000026

0.0033

  

24

HbA1c

rs721346

11

103242667

0.000027

0.5054

PDGFD

 

25

HOMA-IR

rs300703

2

229416

0.000027

0.1086

SH3YL1

 

2b. Ordered by FBAT p-value

1

HbA1c

rs7719971

5

119990475

0.0324

0.00002

  

2

HOMA-IR

rs10425253

19

36038375

0.0005

0.00002

  

3

HOMA-IR

rs10511886

9

31826555

0.0933

0.00002

  

4

Incident DM

rs256962

5

114970610

0.0030

0.00002

TICAM2

 

5

Fasting Insulin

rs10494321

1

154721517

0.0029

0.00002

KIRREL

 

6

Incident DM

rs1549415

8

120252290

0.0332

0.00002

  

7

FPG

rs6910169

6

112990680

0.0062

0.00003

  

8

HbA1c

rs2400207

5

145360290

0.0305

0.00003

SH3RF2

 

9

HbA1c

rs991672

5

120002649

0.0272

0.00003

  

10

ISI_0-120

rs633082

9

107992360

0.0068

0.00004

  

11

tFPG

rs10496802

2

139478604

0.0172

0.00004

  

12

FPG

rs7684538

4

96725483

0.0202

0.00005

UNC5C

 

13

Fasting Insulin

rs963328

1

209426056

0.2949

0.00005

FLVCR

 

14

Incident DM

rs2432961

8

120266196

0.0069

0.00005

  

15

Incident DM

rs2468168

8

120238819

0.0426

0.00006

COLEC10

 

16

ISI_0-120

rs6594987

5

116256211

0.1298

0.00006

  

17

HOMA-IR

rs10511885

9

31821043

0.1250

0.00007

  

18

tFPG

rs10487976

7

122429976

0.0076

0.00007

SLC13A1

 

19

tFPG

rs2204295

7

122432041

0.0060

0.00007

SLC13A1

 

20

HbA1c

rs9325002

5

145406441

0.0295

0.00007

SH3RF2

 

21

HbA1c

rs1365371

8

129018405

0.0298

0.00007

  

22

HOMA-IR

rs2020362

19

36033107

0.0016

0.00009

  

23

Incident DM

rs1489092

3

76204196

0.0535

0.00010

  

24

ISI_0-120

rs2942321

5

19365227

0.4753

0.00010

  

25

ISI_0-120

rs10501828

11

94883857

0.0067

0.00010

  

2c. LOD > 2, Ordered by Lod Score

No.

Trait

SNP or STR

Chr

Physical position

Marshfield cM

Max LOD

Physical position

       

Lower bound where LOD = 1.5

Upper bound where LOD = 1.5

1

FPG

rs1890843

1

207225242

230.9

3.64

205357346

209935673

2

HbA1c

rs1463697

3

195278503

217.5

3.16

191762568

197963623

3

HOMA-IR

rs10513843

3

190998205

209.4

3.08

188644318

193634077

4

Fasting insulin

rs4803953

19

51650847

70.1

2.98

43726908

56203682

5

HbA1c

rs10510060

10

121853460

139.9

2.41

119524854

125827901

6

HOMA-IR

rs10500300

19

53439815

73.3

2.36

42063572

57117898

7

tFPG

rs2837076

21

39850406

38.7

2.36

34879124

41000937

8

HbA1c

rs10497392

2

174176465

177.5

2.30

153549351

177629785

9

tFPG

rs876362

2

80327060

102.6

2.29

70585709

112151653

10

Fasting insulin

rs10513860

3

191902243

212.8

2.21

187447466

196384998

11

FPG

rs1882347

2

164233821

167.3

2.20

146837297

171264176

12

FPG

rs10512296

9

102073227

108.4

2.15

91062454

107815119

13

tFPG

ATA20G07

5

180431

0.0

2.10

180431

2855065

14

tFPG

rs2444962

15

31214059

24.7

2.05

23732660

35462954

15

HbA1c

rs10494382

1

159838765

175.2

2.03

157467831

200055293

Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us