Skip to main content

Table 1 Type 2 diabetes-related quantitative traits in 1087 Framingham Offspring Study subjects with 100K genotype data

From: Genome-wide association with diabetes-related traits in the Framingham Heart Study

Trait

Number of traits

Offspring Exam Cycle

Cohort Exam Cycle

Adjustment *

Number with Genotype and Trait Levels †

Fasting plasma glucose (FPG)

1

5, 7

-

age, age2 age, age2, BMI

1,027

Hemoglobin A1c (HbA1c)

1

5, 7

-

age, age2 age, age2, BMI

623

28 yr time averaged FPG (tFPG)

1

1–7

-

age, age2 age, age2, BMI

1,087

Fasting insulin

1

5, 7

-

age, age2 age, age2, BMI

982

Homeostasis model insulin resistance (HOMA-IR)

1

5

-

age, age2 age, age2, BMI

980

0–120 min insulin sensitivity (ISI_0-120)

1

5

-

age, age2 age, age2, BMI

935

Incident type 2 diabetes

1

1–7

-

age, age2 age, age2, BMI

91 with diabetes

1,083 without diabetes

Adiponectin

1

7

-

age, age2 age, age2, BMI

828

Resistin

1

7

-

age, age2 age, age2, BMI

831

  1. * Traits were modeled as log(trait value) in sex-specific models. Residuals from these models were tested as quantitative traits associated with SNP genotype, and ranked residuals were used in linkage analyses.
  2. † For traits with data at both exams 5 and 7, numbers are given for subjects with data at exam 5