Table 1 Description of hemostatic factors, hematological phenotypes, and covariates adjustment
Phenotype | Number of adjusted phenotypes | Offsrping cohort exam cycles†| Sample size (min-max) | Covariates adjusted |
|---|---|---|---|---|
Hemostatic factors: | Â | Â | Â | Â |
fibrinogen | 4 | 5, 6, 7 and average | 986–1073 | age (and its squared and cubic terms), sex, body mass index, prevalent cardiovascular disease, current cigarette smoking, hypertension treatment, systolic blood pressure, diastolic blood pressure, estrogen therapy (women only), alcohol intake, triglycerides, diabetes, total cholesterol, and the ratio of total cholesterol to high-density lipoprotein cholesterol. |
PAI-1 | 3 | 5, 6 and average | 788–1037 |  |
tPA | 1 | 5 | 786 | Â |
vWF | 1 | 5 | 883 | Â |
FVII | 1 | 5 | 886 | Â |
D-dimer | 1 | 5 | 987 | Â |
Hematological and rheological phenotypes | Â | Â | Â | Â |
platelet aggregation (ADP-induced) | 1 | 5 | 724 | Â |
platelet aggregation (collagen-induced) | 1 | 5 | 702 | Â |
platelet aggregation (Epi-induced) | 1 | 5 | 719 | Â |
Viscosity | 1 | 5 | 832 | Â |
Hgb | 3 | 1, 2, and average | 903–1066 | age, sex, height, weight, high-density lipoprotein cholesterol, total serum protein, alcohol intake, triglycerides, and current cigarette smoking |
RBCC | 3 | 1, 2, and average | 903–1062 |  |
MCH | 3 | 1, 2, and average | 903–1062 |  |
Hematocrit* | 3 | 1, 2, and average | 903–1062 |  |
MCV | 3 | 1, 2, and average | 903–1062 |  |
WBC* | 3 | 1, 2, and average | 903–1062 |  |