MRPS18CP2 alleles and DEFA3absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene

Table 1 DEFA3 gene absence in A1555G patients and control subjects.

SAMPLES	Phenotype	*DEFA3*	NO *DEFA3*	p-value*
A1555G carriers (n = 213)	Deaf (n = 135)	115 (85%)	20 (15%)	0.678
	Hearing (n = 78)	69 (88%)	9 (12%)
A1555G carriers (n = 213)	Deaf & Hearing	184 (86%)	29 (14%)	0.283
A1555G index cases (n = 55)	Deaf	45 (82%)	10 (18%)	0.697
A1555G linked samples (n = 55)	Deaf & Hearing	52 (95%)	3 (5%)	0.171
Controls (n = 336)		294 (87.5%)	42 (12.5%)

* Between groups chi-square p-value resulting from the comparison of deaf vs hearing carriers or carriers vs. control population subjects.

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