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Table 3 Association analyses in type 1 diabetes families.

From: The candidate genes TAF5L, TCF7, PDCD1 , IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes

    

Transmission/disequilibrium test

  

Parent-child-trios (families)

Parental MAF

Minor allele

RR (95% CI)

P

    

Transmitted

Untransmitted

  

TAF5L

A1159C (rs3212227)

2,645 (2,515)

46.8

1,299

1,400

0.92 (0.85–0.99)

0.0519

PDCD1

7146G>A (rs11568821)

3,125 (2,742)

9.3

516

538

0.96 (0.85–1.08)

0.498

PDCD1

872C>T (rs2227981)

2,190 (1,831)

42.5

1,111

1,043

1.07 (0.98–1.16)

0.143

TCF7

C883A (rs5742913)

1,556 (1,224)

11.2

327

314

1.04 (0.89–1.21)

0.608

IL12B

A1159C (rs3212227)

3,015 (2,606)

18.9

949

933

1.02 (0.93–1.12)

0.712

IL6

174G>C (rs1800795)

2,803 (2,651)

47.0

1,411

1,360

1.04 (0.97–1.12)

0.333

TBX21

His33Gln (rs2240017)

1,989 (1,374)

2.7

111

100

1.11 (0.85–1.45)

0.449

CD40

Kozak (rs1883832)

1,446 (795)

24.1

522

542

0.96 (0.85–1.08)

0.540

  1. MAF = minor allele frequency, RR = relative risk for minor allele, 95% CI = 95% confidence interval.
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BMC Medical Genetics

ISSN: 1471-2350

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