Genetic variants of Complement factor H gene are not associated with premature coronary heart disease: a family-based study in the Irish population

Table 3 Association tests between 6 SNPs and premature heart disease performed using the Transmission Disequilibrium Test/sibling Transmission Disequilibrium Test (TDT/S-TDT)

SNP name	Coding variant	Allele	Number of informative families	W¹	Expected(W)	Variance(W)	P-value
rs 800292	I62V	CT	218	289	288.7	60.4	0.97
rs 1061170	Y402H	CT	323	300	294.9	107.0	0.62
rs 2274700	A473A	AG	203	132	128.2	57.0	0.62
rs 3753396	Q672Q	AG	218	314	310.7	61.1	0.67
rs 419137		AC	181	253	254.0	48.4	0.89
rs 2284664		AG	216	142	141.3	59.9	0.93

¹ W = X+Y where X is the number of transmissions of the first-mentioned allele from heterozygote parents to affected siblings (TDT) and Y is the number of occurrences of the first-mentioned allele in affected sibs in remaining informative families (S-TDT).
The 6 SNPs are arranged in an order according to their positions in the CFH gene.

ISSN: 1471-2350