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Table 3 Distribution of the ATP1A4, CAS Q1, KCNJ9, KCNJ10, and CACNA1E SNPs in migraineurs and controls of original sample

From: Association analysis of chromosome 1 migraine candidate genes

  N Alleles    Genotypes  
Group (alleles) C T CC CT TT
ATP 1A4 SNP rs 6427504      
Migraine 466 167 (35.8%) 299 (64.2%) 30 (12.9%) 107 (45.9%) 96 (41.2%)
Male 64 22 (34.4%) 42 (65.6%) 4 (12.5%) 14 (43.8%) 14 (43.8 %)
Female 402 145 (36.1%) 257 (63.9%) 26 (12.9%) 93 (46.3%) 82 (40.8%)
MA 382 139 (36.4%) 243 (63.6%) 24 (12.6%) 91 (47.6%) 76 (39.8%)
MO 74 26 (35.1%) 48 (64.9%) 5 (13.6%) 16 (43.2%) 16 (43.2%)
Control 416 167 (40%) 251 (60%) 38 (18.2%) 91 (43.5%) 80 (38.3%)
Male 66 25 (37.9%) 41 (62.1%) 5 (15.2%) 15 (45.5%) 13 (39.3%)
Female 352 142 (40.3%) 210 (59.7%) 33 (18.8%) 76 (43.1 %) 67 (38.1%)
Total case vs control   X 2 = 1.59 P = 0.207   X 2 = 2.39 P = 0.302
Subtype MA vs cont:   X 2 = 1.07 P = 0.30   X 2 = 2.46 P = 0.29
Subtype MO vs cont   X 2 = 0.61 P = 0.43   X 2 = 0.59 P = 0.74
  N Alleles    Genotypes  
Group (alleles) C T CC CT TT
CAS Q1 SNP rs 3747623      
Migraine 446 288 (63.2%) 168 (36.8%) 93 (40.8%) 102 (44.7%) 33 (14.5%)
Male 68 45 (66.2%) 23 (33.8%) 16 (47.1%) 13 (38.2%) 5 (14.7 %)
Female 388 243 (62.6%) 145 (37.4%) 77 (39.7%) 89 (45.9%) 28 (14.4%)
MA 376 235 (62.5%) 141 (37.5%) 76 (40.4%) 83 (44.1%) 29 (15.4%)
MO 66 42 (63.6%) 24 (36.4%) 12 (36.4%) 18 (54.3%) 3 (9.1%)
Control 430 281 (65.3%) 149 (34.7%) 89 (41.4%) 103 (47.9%) 23 (10.7%)
Male 66 38 (59.4%) 26 (40.6%) 11 (34.4%) 16 (50%) 5 (15.6%)
Female 352 243 (66.4%) 123 (33.6%) 78(47.1%) 87 (38.2 %) 18 (14.7%)
Total case vs control   X 2 = 0.46 P = 0.496   X 2 = 1.48 P = 0.473
Subtype MA vs cont:   X 2 = 0.71 P = 0.40   X 2 = 2.07 P = 0.36
Subtype MO vs cont   X 2 = 0.07 P = 0.78   X 2 = 0.51 P = 0.77
  N Alleles    Genotypes  
Group (alleles) C T CC CT TT
KCNJ9 SNP rs 2494211      
Migraine 466 322 (66.5%) 162 (33.5%) 113 (46.7%) 96 (39.7%) 33 (13.6%)
Male 70 41 (58.6%) 29 (41.4%) 12 (34.3%) 17 (48.6%) 6 (17.1 %)
Female 414 281 (67.9%) 133 (32.1%) 101 (48.8%) 79 (38.2%) 27 (13%)
MA 392 262 (66.8%) 130 (33.2%) 94 (48%) 74 (37.8%) 28 (14.2%)
MO 74 48 (64.9%) 26 (35.1%) 15 (40.5%) 18 (48.6%) 4 (10.9%)
Control 486 308 (63.4%) 178 (36.6%) 95 (39.1%) 118 (48.6%) 30 (12.3%)
Male 70 41 (58.6%) 29 (41.4%) 11 (31.4%) 19 (54.3%) 5 (14.3%)
Female 416 267 (64.2%) 149 (35.8%) 84 (40.4%) 99 (47.6 %) 25 (12%)
Total case vs control   X 2 = 1.06 P = 0.303   X 2 = 3.96 P = 0.138
Subtype MA vs cont:   X 2 = 1.14 P = 0.28   X 2 = 5.19 P = 0.07
Subtype MO vs cont   X 2 = 0.06 P = 0.80   X 2 = 0.08 P = 0.96
  N Alleles    Genotypes  
Group (alleles) C T CC CT TT
KCNJ10 SNP rs1130183      
Migraine 440 408 (92.7%) 32 (7.3%) 189 (85.9%) 30 (13.6%) 1 (0.5%)
Male 66 59 (89.4%) 7 (10.6%) 26 (78.8%) 7 (21.2%) 0
Female 374 349 (93.3%) 25 (6.7%) 163 (87.2%) 23 (12.3%) 1 (0.5%)
MA 356 332 (93.3%) 24 (6.7%) 155 (87.1%) 22 (12.4%) 1 (0.6%)
MO 66 63 (95.5%) 3 (4.5%) 30 (90.9%) 3 (9.1%) 0
Control 422 394 (93.4%) 28 (6.6%) 189 (89.6%) 16 (7.6%) 6 (2.8%)
Male 62 57 (91.9%) 5 (8.1%) 27 (87.1%) 3 (9.7%) 1 (3.2%)
Female 360 337 (93.6%) 23 (6.4%) 162 (90%) 13 (7.2 %) 5 (2.8%)
Total case vs control   X 2 = 0.14 P = 0.713   X 2 = 7.65 P = 0.02
Subtype MA vs cont:   X 2 = 0 P = 0.95   X 2 = 5.12 P = 0.08
Subtype MO vs cont   X 2 = 0.42 P = 0.52   X 2 = 1.02 P = 0.59
  N Alleles    Genotypes  
Group (alleles) A G AA AG GG
CACNA1E SNP rs 704326      
Migraine 464 384 (83%) 80 (17%) 154 (66%) 76 (33%) 2 (1%)
Male 142 134 (94.4%) 8 (5.6%) 63 (88.7%) 8 (11.3%) 0
Female 308 240 (77.9%) 68 (22.1%) 89 (57.8%) 62 (40.3%) 3 (1.9%)
MA 276 224 (81%) 52 (19%) 88 (64%) 48 (35%) 2 (1%)
MO 188 160 (85%) 28 (15%) 66 (70%) 28 (30%) 0
Control 424 341 (80%) 83 (20%) 132 (63%) 77 (36%) 3 (1%)
Male 116 101 (87.1%) 15 (12.9%) 43 (74.1%) 15 (25.9%) 0
Female 308 240 (77.9%) 68 (22.1%) 89(57.8%) 62 (40.3 %) 3 (1.9%)
Total case vs control   X 2 = 1.00 P = 0.6   X 2 = 0.81 P = 0.37
Subtype MA vs cont:   X 2 = 0.06 P = 0.80   X 2 = 0.09 P = 0.96
Subtype MO vs cont   X 2 = 1.92 P = 0.16   X 2 = 2.78 P = 0.25
  1. MO, migraine without aura; MA, migraine with aura