Table 3 Distribution of the ATP1A4, CAS Q1, KCNJ9, KCNJ10, and CACNA1E SNPs in migraineurs and controls of original sample

N

Alleles

Genotypes

Group

(alleles)

C

T

CC

CT

TT

ATP 1A4 SNP

rs 6427504

Migraine

466

167 (35.8%)

299 (64.2%)

30 (12.9%)

107 (45.9%)

96 (41.2%)

Male

64

22 (34.4%)

42 (65.6%)

4 (12.5%)

14 (43.8%)

14 (43.8 %)

Female

402

145 (36.1%)

257 (63.9%)

26 (12.9%)

93 (46.3%)

82 (40.8%)

MA

382

139 (36.4%)

243 (63.6%)

24 (12.6%)

91 (47.6%)

76 (39.8%)

MO

74

26 (35.1%)

48 (64.9%)

5 (13.6%)

16 (43.2%)

16 (43.2%)

Control

416

167 (40%)

251 (60%)

38 (18.2%)

91 (43.5%)

80 (38.3%)

Male

66

25 (37.9%)

41 (62.1%)

5 (15.2%)

15 (45.5%)

13 (39.3%)

Female

352

142 (40.3%)

210 (59.7%)

33 (18.8%)

76 (43.1 %)

67 (38.1%)

Total case vs control

X ² = 1.59

P = 0.207

X ² = 2.39

P = 0.302

Subtype MA vs cont:

X ² = 1.07

P = 0.30

X ² = 2.46

P = 0.29

Subtype MO vs cont

X ² = 0.61

P = 0.43

X ² = 0.59

P = 0.74

N

Alleles

Genotypes

Group

(alleles)

C

T

CC

CT

TT

CAS Q1 SNP

rs 3747623

Migraine

446

288 (63.2%)

168 (36.8%)

93 (40.8%)

102 (44.7%)

33 (14.5%)

Male

68

45 (66.2%)

23 (33.8%)

16 (47.1%)

13 (38.2%)

5 (14.7 %)

Female

388

243 (62.6%)

145 (37.4%)

77 (39.7%)

89 (45.9%)

28 (14.4%)

MA

376

235 (62.5%)

141 (37.5%)

76 (40.4%)

83 (44.1%)

29 (15.4%)

MO

66

42 (63.6%)

24 (36.4%)

12 (36.4%)

18 (54.3%)

3 (9.1%)

Control

430

281 (65.3%)

149 (34.7%)

89 (41.4%)

103 (47.9%)

23 (10.7%)

Male

66

38 (59.4%)

26 (40.6%)

11 (34.4%)

16 (50%)

5 (15.6%)

Female

352

243 (66.4%)

123 (33.6%)

78(47.1%)

87 (38.2 %)

18 (14.7%)

Total case vs control

X ² = 0.46

P = 0.496

X ² = 1.48

P = 0.473

Subtype MA vs cont:

X ² = 0.71

P = 0.40

X ² = 2.07

P = 0.36

Subtype MO vs cont

X ² = 0.07

P = 0.78

X ² = 0.51

P = 0.77

N

Alleles

Genotypes

Group

(alleles)

C

T

CC

CT

TT

KCNJ9 SNP

rs 2494211

Migraine

466

322 (66.5%)

162 (33.5%)

113 (46.7%)

96 (39.7%)

33 (13.6%)

Male

70

41 (58.6%)

29 (41.4%)

12 (34.3%)

17 (48.6%)

6 (17.1 %)

Female

414

281 (67.9%)

133 (32.1%)

101 (48.8%)

79 (38.2%)

27 (13%)

MA

392

262 (66.8%)

130 (33.2%)

94 (48%)

74 (37.8%)

28 (14.2%)

MO

74

48 (64.9%)

26 (35.1%)

15 (40.5%)

18 (48.6%)

4 (10.9%)

Control

486

308 (63.4%)

178 (36.6%)

95 (39.1%)

118 (48.6%)

30 (12.3%)

Male

70

41 (58.6%)

29 (41.4%)

11 (31.4%)

19 (54.3%)

5 (14.3%)

Female

416

267 (64.2%)

149 (35.8%)

84 (40.4%)

99 (47.6 %)

25 (12%)

Total case vs control

X ² = 1.06

P = 0.303

X ² = 3.96

P = 0.138

Subtype MA vs cont:

X ² = 1.14

P = 0.28

X ² = 5.19

P = 0.07

Subtype MO vs cont

X ² = 0.06

P = 0.80

X ² = 0.08

P = 0.96

N

Alleles

Genotypes

Group

(alleles)

C

T

CC

CT

TT

KCNJ10 SNP

rs1130183

Migraine

440

408 (92.7%)

32 (7.3%)

189 (85.9%)

30 (13.6%)

1 (0.5%)

Male

66

59 (89.4%)

7 (10.6%)

26 (78.8%)

7 (21.2%)

0

Female

374

349 (93.3%)

25 (6.7%)

163 (87.2%)

23 (12.3%)

1 (0.5%)

MA

356

332 (93.3%)

24 (6.7%)

155 (87.1%)

22 (12.4%)

1 (0.6%)

MO

66

63 (95.5%)

3 (4.5%)

30 (90.9%)

3 (9.1%)

0

Control

422

394 (93.4%)

28 (6.6%)

189 (89.6%)

16 (7.6%)

6 (2.8%)

Male

62

57 (91.9%)

5 (8.1%)

27 (87.1%)

3 (9.7%)

1 (3.2%)

Female

360

337 (93.6%)

23 (6.4%)

162 (90%)

13 (7.2 %)

5 (2.8%)

Total case vs control

X ² = 0.14

P = 0.713

X ² = 7.65

P = 0.02

Subtype MA vs cont:

X ² = 0

P = 0.95

X ² = 5.12

P = 0.08

Subtype MO vs cont

X ² = 0.42

P = 0.52

X ² = 1.02

P = 0.59

N

Alleles

Genotypes

Group

(alleles)

A

G

AA

AG

GG

CACNA1E SNP

rs 704326

Migraine

464

384 (83%)

80 (17%)

154 (66%)

76 (33%)

2 (1%)

Male

142

134 (94.4%)

8 (5.6%)

63 (88.7%)

8 (11.3%)

0

Female

308

240 (77.9%)

68 (22.1%)

89 (57.8%)

62 (40.3%)

3 (1.9%)

MA

276

224 (81%)

52 (19%)

88 (64%)

48 (35%)

2 (1%)

MO

188

160 (85%)

28 (15%)

66 (70%)

28 (30%)

0

Control

424

341 (80%)

83 (20%)

132 (63%)

77 (36%)

3 (1%)

Male

116

101 (87.1%)

15 (12.9%)

43 (74.1%)

15 (25.9%)

0

Female

308

240 (77.9%)

68 (22.1%)

89(57.8%)

62 (40.3 %)

3 (1.9%)

Total case vs control

X ² = 1.00

P = 0.6

X ² = 0.81

P = 0.37

Subtype MA vs cont:

X ² = 0.06

P = 0.80

X ² = 0.09

P = 0.96

Subtype MO vs cont

X ² = 1.92

P = 0.16

X ² = 2.78

P = 0.25