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Table 2 Analysis of Serum measurements and PPAR alpha (L162V) in Caucasians

From: PPARα L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males

Serum Measurement Group Covariates P-value N; Adjusted mean ± SEM p-value for significantly different means % variation explained by genotype; LRT p-value
Triglycerides All subjects Age 0.0026 CC (N = 500; 102.92 ± 4.49)*
CG (N = 71; 146.80 ± 11.84)*
GG (N = 7; 114.99 ± 37.98)
*p = 0.0018 2.0%; 0.0025
  Females Age 0.0474 CC (N = 307; 94.76 ± 2.59)*
CG (N = 45; 111.11 ± 6.77)*
GG (N = 7; 114.72 ± 17.17)
NONE 1.7%; 0.0458
  Males Age 0.0040 CC (N = 193; 116.15 ± 10.82)*
CG (N = 26; 207.49 ± 29.49)*
*p = 0.0040 3.8%; 0.0037
HDL All subjects Age 0.0076 CC (N = 500; 48.13 ± 0.56)
CG (N = 70; 44.67 ± 1.48)*
GG (N = 7; 58.43 ± 4.74)*
*p = 0.0173 1.7%; 0.0073
  Females Age NS    
  Males Age 0.0017 CC (N = 193; 41.77 ± 0.78)*
CG (N = 26; 34.54 ± 2.13)*
*p = 0.0017 4.4%; 0.0015
Cholesterol All subjects Age NS    
  Females Age NS    
  Males Age NS    
VLDL-TG All subjects Age NS    
  Females Age 0.0441 CC (N = 307; 18.94 ± 0.52)*
CG (N = 45; 22.29 ± 1.35)*
GG (N = 7; 22.77 ± 3.43)
NONE 1.7%; 0.0426
  Males Age NS    
LDL All subjects Age NS    
  Females Age NS    
  Males Age NS    
Fasting glucose All subjects Age NS    
  Females Age 0.0440 CC (N = 307; 85.78 ± 0.41)
CG (N = 45; 83.65 ± 1.03)
GG (N = 7; 89.71 ± 2.58)
NONE 1.5%;0.0426
  Males Age NS    
Fasting insulin All subjects Age NS    
  Females Age NS    
  Males Age NS