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Table 1 Cost-effectiveness model: input variables and sources

From: Cost-utility analysis of genetic screening in families of patients with germline MUTYH mutations

Variable Base case Assumption (costs indexed at 2006) Range Source
Prevalence of MUTYH mutations in population 1.5% 1–2% Al Tassan 2002, Croituro 2004, own data (unpublished) [1;6]
Prevalence of CRC in MAP patients 60% 40–70% Nielsen 2005, Sampson 2003, Gismondi 2004 [2–4]
Mean age of diagnosis of CRC in MAP patients 49 year   Nielsen 2005, Sampson 2003, Gismondi 2004 [2–4]
Baseline cure rate in MAP patients after CRC 52% 30–60% IKA/Association of Comprehensive Cancer Centers, [13]
Mean number of children per family 2 children   40 Dutch MAP patients (own data, unpublished)
Life expectancy after CRC Table*   IKA/Association of Comprehensive Cancer Centers, [13]
Life expectancy total population Table*   Central Bureau of Statistics (Statistics Netherlands), [32]
Utility after CRC 0.90 0.85–0.95 [24]- utility 9 month after surgery- mean [22] [23]
Spouses compliance to testing 75% 0–100% See methods, own data, Rowley 2004 [11]
Childrens' compliance to testing 75% 50–100% Rowley 2004 [11]
Age start screening children 25 year 20–25 year See text
CRC costs   50–200% van den Brink 2004 [24]
• initial treatment and recurrence 21,330   
• continuing care 2130/year   
• non-health care (productivity) 11,060   
Costs of genetic testing in a DNA diagnostic laboratory social costs (travel/production) 645€
95€
200–1000€ Costs genetic testing Leiden University Medical Center (LUMC) [25]
Colonoscopy costs (including polypectomy and complications) 561€ (480€ + 81€)   LUMC, Heitman 2005 [18]
Social costs (travel/production) 70€   Oostenbrink 2004 [25]
Effectiveness colonoscopy (reduction in CRC cases) 90% 70–80% Winawer 1993 [16]
Effectiveness FOBT (reduction in mortality) 11% 10–30% Kronborg 2004 [19] Faivre 2004 [20]
FOBT 65€ (18€ medical & 47€ time)   Gyrd-Hansen 1998, Oostenbrink 2004 [7] [25]
Discount rate 4% 3–5% Oostenbrink 2004 [25]
  1. * Extensive tables, please contact corresponding author for detailed information.