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Table 1 Effects of the TCF7L2 rs7903146 T allele on birth and adult parameters in SGA and AGA individuals

From: TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

Quantitative traits AGA SGA T-test AGA by genotype LR SGA by genotype LR Interaction
  n = 764 n = 627 p value C/C C/T T/T p value C/C C/T T/T p value p value
a Birth weight (g) 3366 ± 267 2614 ± 303 8 × 10 -306 3364 ± 268 3376 ± 260 3334 ± 294 0.78 2623 ± 306 2601 ± 309 2622 ± 258 0.64 0.77
a Birth length (cm) 50.35 ± 1.2 47.68 ± 2.1 2 × 10 -152 50.3 ± 1.21 50.4 ± 1.1 50.3 ± 1.2 0.61 47.8 ± 2.2 47.6 ± 2.0 47.7 ± 2.0 0.80 0.68
a Ponderal index (kg/m 3 ) 26.36 ± 1.6 24.19 ± 2.3 5 × 10 -79 26.4 ± 1.7 26.3 ± 1.6 26.17 ± 1.6 0.41 24.2 ± 2.3 24.2 ± 2.4 24.1 ± 2.5 0.84 0.80
BMI (kg/m 2 ) 22.72 ± 3.97 22.51 ± 4.33 0.36 22.7 ± 3.7 227 ± 4.1 22.7 ± 4.5 0.90 22.9 ± 4.5 22.0 ± 3.9 22.6 ± 5 0.66 0.81
Waist to hip ratio (no unit) 0.8 ± 0.08 0.81 ± 0.08 0.20 0.8 ± 0.1 0.81 ± 0.1 0.79 ± 0.1 0.43 0.8 ± 0.1 0.8 ± 0.1 0.8 ± 0.1 0.83 0.86
HDL cholesterol (mmol/l) 1.43 ± 0.35 1.4 ± 0.36 0.06 1.4 ± 0.3 1.4 ± 0.3 1.5 ± 0.4 0.32 1.4 ± 0.4 1.4 ± 0.3 1.4 ± 0.3 0.68 0.76
Triglyceridemia (mmol/l) 1.03 ± 0.53 1.1 ± 0.59 0.01 1.0 ± 0.51 1.09 ± 0.55 0.88 ± 0.49 0.33 1.14 ± 0.64 1.04 ± 0.5 1.2 ± 0.61 0.34 0.21
Fasting glucose (g/l) 0.86 ± 0.06 0.87 ± 0.07 0.14 0.86 ± 0.07 0.86 ± 0.07 0.88 ± 0.07 0.002 0.87 ± 0.07 0.86 ± 0.06 0.88 ± 0.11 0.64 0.13
Ln [Fasting insulin (mU/l)] 1.46 ± 0.5 1.53 ± 0.58 0.03 1.5 ± 0.5 1.5 ± 0.5 1.4 ± 0.6 0.42 1.6 ± 0.6 1.5 ± 0.5 1.5 ± 0.7 0.48 0.90
Ln [HOMA-B (no unit)] 4.24 ± 0.56 4.29 ± 0.6 0.12 4.27 ± 0.55 4.23 ± 0.56 4.13 ± 0.61 0.03 4.32 ± 0.64 4.26 ± 0.53 4.23 ± 0.67 0.71 0.27
Ln [HOMA-IR (no unit)] -0.09 ± 0.51 -0.02 ± 0.61 0.02 -0.08 ± 0.52 -0.10 ± 0.49 -0.10 ± 0.58 0.73 0.02 ± 0.66 -0.05 ± 0.52 -0.07 ± 0.71 0.52 0.74
  1. SGA: Small Gestational Age
  2. AGA: Appropriate for Gestational Age birth weight
  3. Insul. Index: Insulogenic index
  4. a: Birth parameters
  5. T-test: Student's T-test
  6. LR: Linear regression models (every adjustments are presented in Subjects and Methods)
  7. Birth status (AGA/SGA) × genotype interactions were presented on the right side of the table