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Table 1 Effects of the TCF7L2 rs7903146 T allele on birth and adult parameters in SGA and AGA individuals

From: TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

Quantitative traits

AGA

SGA

T-test

AGA by genotype

LR

SGA by genotype

LR

Interaction

 

n = 764

n = 627

p value

C/C

C/T

T/T

p value

C/C

C/T

T/T

p value

p value

a Birth weight (g)

3366 ± 267

2614 ± 303

8 × 10 -306

3364 ± 268

3376 ± 260

3334 ± 294

0.78

2623 ± 306

2601 ± 309

2622 ± 258

0.64

0.77

a Birth length (cm)

50.35 ± 1.2

47.68 ± 2.1

2 × 10 -152

50.3 ± 1.21

50.4 ± 1.1

50.3 ± 1.2

0.61

47.8 ± 2.2

47.6 ± 2.0

47.7 ± 2.0

0.80

0.68

a Ponderal index (kg/m 3 )

26.36 ± 1.6

24.19 ± 2.3

5 × 10 -79

26.4 ± 1.7

26.3 ± 1.6

26.17 ± 1.6

0.41

24.2 ± 2.3

24.2 ± 2.4

24.1 ± 2.5

0.84

0.80

BMI (kg/m 2 )

22.72 ± 3.97

22.51 ± 4.33

0.36

22.7 ± 3.7

227 ± 4.1

22.7 ± 4.5

0.90

22.9 ± 4.5

22.0 ± 3.9

22.6 ± 5

0.66

0.81

Waist to hip ratio (no unit)

0.8 ± 0.08

0.81 ± 0.08

0.20

0.8 ± 0.1

0.81 ± 0.1

0.79 ± 0.1

0.43

0.8 ± 0.1

0.8 ± 0.1

0.8 ± 0.1

0.83

0.86

HDL cholesterol (mmol/l)

1.43 ± 0.35

1.4 ± 0.36

0.06

1.4 ± 0.3

1.4 ± 0.3

1.5 ± 0.4

0.32

1.4 ± 0.4

1.4 ± 0.3

1.4 ± 0.3

0.68

0.76

Triglyceridemia (mmol/l)

1.03 ± 0.53

1.1 ± 0.59

0.01

1.0 ± 0.51

1.09 ± 0.55

0.88 ± 0.49

0.33

1.14 ± 0.64

1.04 ± 0.5

1.2 ± 0.61

0.34

0.21

Fasting glucose (g/l)

0.86 ± 0.06

0.87 ± 0.07

0.14

0.86 ± 0.07

0.86 ± 0.07

0.88 ± 0.07

0.002

0.87 ± 0.07

0.86 ± 0.06

0.88 ± 0.11

0.64

0.13

Ln [Fasting insulin (mU/l)]

1.46 ± 0.5

1.53 ± 0.58

0.03

1.5 ± 0.5

1.5 ± 0.5

1.4 ± 0.6

0.42

1.6 ± 0.6

1.5 ± 0.5

1.5 ± 0.7

0.48

0.90

Ln [HOMA-B (no unit)]

4.24 ± 0.56

4.29 ± 0.6

0.12

4.27 ± 0.55

4.23 ± 0.56

4.13 ± 0.61

0.03

4.32 ± 0.64

4.26 ± 0.53

4.23 ± 0.67

0.71

0.27

Ln [HOMA-IR (no unit)]

-0.09 ± 0.51

-0.02 ± 0.61

0.02

-0.08 ± 0.52

-0.10 ± 0.49

-0.10 ± 0.58

0.73

0.02 ± 0.66

-0.05 ± 0.52

-0.07 ± 0.71

0.52

0.74

  1. SGA: Small Gestational Age
  2. AGA: Appropriate for Gestational Age birth weight
  3. Insul. Index: Insulogenic index
  4. a: Birth parameters
  5. T-test: Student's T-test
  6. LR: Linear regression models (every adjustments are presented in Subjects and Methods)
  7. Birth status (AGA/SGA) × genotype interactions were presented on the right side of the table