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Table 2 Allele and genotype frequencies (F) of SNPs and their association status with chronic renal insufficiency

From: Association of TGFβ1, TNFα, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians

SNPs Allele frequency Genotype frequency Association
  DM
F (* n)
CRI
F (* n)
DM
F (** n)
CRI
F (** n)
Allele
(df = 1)
Genotype
(df = 2)
TGFβ1
G>A (-800)
G = 0.93 (418)
A = 0.07 (32)
G = 0.91 (356)
A = 0.09 (72)
GG = 0.87 (196)
GA = 0.12 (27)
AA = 0.01 (3)
GG = 0.84(165)
GA = 0.15 (29)
AA = 0.01 (2)
χ2 = 0.60;
P = 0.44
χ2 = 1.16;
P = 0.56
TGFβ1
C>T (-509)
C = 0.875 (388)
T = 0.125 (112)
C = 0.84 (330)
T = 0.16 (124)
CC = 0.77 (171)
CT = 0.21 (47)
TT = 0.02 (4)
CC = 0.72 (141)
CT = 0.24 (47)
TT = 0.04 (8)
χ2 = 1.24;
P = 0.27
χ2 = 1.23;
P = 0.54
TNFα
G>A (-308)
Promoter
G = 0.93 (416)
A = 0.07 (32)
G = 0.96 (376)
A = 0.04 (16)
GG = 0.87 (195)
GA = 0.12 (27)
AA = 0.01 (2)
GG = 0.91 (178)
GA = 0.08 (16)
AA = 0.01 (2)
χ2 = 2.31;
P = 0.13
χ2 = 2.43;
P = 0.12
CCR2
C>T
Val64Ile
C = 0.91 (410)
T = 0.09 (40)
C = 0.94 (368)
T = 0.06 (24)
CC = 0.84 (189)
CT = 0.15 (34)
TT = 0.01 (2)
CC = 0.90 (176)
CT = 0.09 (18)
TT = 0.01 (2)
χ2 = 2.73;
P = 0.10
χ2 = 2.87;
P = 0.24
CCR
5G>A (59029)
G = 0.46 (208)
A = 0.54 (242)
G = 0.38 (148)
A = 0.62 (244)
GG = 0.21 (47)
GA = 0.49 (111)
AA = 0.30 (67)
GG = 0.14 (27)
GA = 0.48 (94)
AA = 0.38 (75)
χ2 = 5.13;
P = 0.02
χ2 = 5.22;
P = 0.07
  1. * Number of respective alleles, and ** genotypes in the study population.