Table 1 Genomic features of small regions containing breakpoints in family data
Family data | Hotspot prediction from HapMap data (Phase 2.1, MR1 model) | Hotspot prediction at UCSCa | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Outlying markers (centromeric, telomeric) | Position (bp) | Size crossover region | Crossovers detected | Hotspot boundaries | Hotspot with (bp) | Hotspot intensity (λ, 95%CI) | Bayes Factor (log) | Hotspot predicted | Recombination intensity (cM/Mb) | |
λ > 10 | λ > 100 | |||||||||
CATCH 48 D22S944 | 17,95198 17,98496 | 32,98 | 1 | 17,963500 17,971900 | 8400 | 762 (466:990) | 3.00 | 3.00 | Yes | 17.36 (Hapmap) 7.02 (Perlegen) |
CATCH 42 D22S311 | 19,449222 19,503575 | 54,353 | 1 | 19,229800 19,237700 | 7900 | 2.6 (1:8) | -1.45 | -3.00 | No | 3.02 (Hapmap) 0.54 (Perlegen) |
CATCH 26 CATCH 30 | 20,706255 20,740881 | 34,626 | 1 | 20,634600 20,640300 | 5700 | 8.5 (1.1:32) | -0.54 | -2.70 | Yes | 40.53 (Hapmap) 17.61 (Perlegen) |
D22S306 CATCH 16 | 20,887523 20,896124 | 8,601 | 1 | 20,881700 20,890000 | 8300 | 131 (17:307) | 3.00 | 0.09 | Yes | 10.62 (Hapmap) 46.50 (Perlegen) |
CATCH 16 CATCH 28 | 20,896124 20,929869 | 33,745 | 1 | -- | -- | -- | -- | -- | Yes | 9.38 (Hapmap) 15.67 (Perlegen) |