Figure 3
From: Rubinstein-Taybi Syndrome: spectrum of CREBBP mutations in Italian patients
Mapping of the five deletions on the CREBBP genomic region. Top: genomic organization of CREBBP with exons represented by black boxes and introns as connecting lines. The intragenic polymorphic loci are positioned across the gene. Middle: BAC clones used for preliminary FISH analysis, indicated by bars. Bottom: deletions are shown by thick lines; deletion ends containing the breakpoints, are represented by dashed lines.