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Table 2 Observed polymorphisms in potassium channels.

From: Potassium channel gene mutations rarely cause atrial fibrillation

Gene Exon Polymorphism Allele frequency Reference
KCNE1 1 G84A, S28S 0.0052 [17]
  1 G112A, G38S 0.24 [18]
  1 C158T, F53F 0.11  
  1 C240T, V80V 0.021 [19]
  1 G253A, D85N 0.021 [15], [20]
  1 G37A, Q13Q 0.0052  
KCNE3 1 T198C, F66F 0.09 [21]
  1 G248A, R83H 0.016 [16]
KCNE4 1 T81C, G27G 0.31  
  1 G69A, S23S 0.005  
  1 C264T, P88P 0.098  
  1 G435T, E145D 0.32  
  1 G471A, E157E 0.031  
  1 3'+18, G>C 0.073  
KCNE5 1 C97T, P33S 0.25  
  1 C207T, F69F 0.021  
KCNJ2 3 C1146T, L383L 0.13  
  1. These are numbered based on the ATG using the cDNA sequence KCNE1 (BC046224), KCNE2 (AF302095), KCNE3 (NM005472.3), KCNE4 (NM080671), KCNE5 (NM012282), KCNJ2 (AF153820). Lower case letters refer to intronic base pairs and are located with respect to the corresponding intron-exon boundaries (5' or 3' +/- number of basepairs). Upper case letters refer to exonic polymorphisms. Polymorphisms that change the coding sequnce are indicated in bold. No polymorphisms were identified in KCNE2.