Table 4 Relationship between RANTES, IL-8, MCP-1 and IL-1α polymorphisms and the presence of nephritis in SLE Spanish patients.
SLE with nephritis | SLE without nephritis | P | OR (95%CI) | |||
|---|---|---|---|---|---|---|
RANTES -403 | n | % | n | % | ||
Genotypes | ||||||
GG | 136 | 73.5 | 230 | 73 | 0.9 | |
GA | 44 | 23.8 | 71 | 22.5 | 0.7 | |
AA | 5 | 2.7 | 14 | 4.4 | 0.3 | |
Alleles | ||||||
G | 54 | 14.6 | 99 | 15.7 | ||
A | 316 | 85.4 | 531 | 84.3 | 0.6 | |
RANTES R3 | n | % | n | % | ||
Genotypes | ||||||
CC | 89 | 77.4 | 225 | 68.8 | 0.08 | |
CT | 23 | 20 | 92 | 28.1 | 0.1 | |
TT | 3 | 2.6 | 10 | 3 | 0.8 | |
Alleles | ||||||
C | 201 | 87.4 | 542 | 82.9 | ||
T | 29 | 12.6 | 112 | 12.1 | 0.1 | |
IL-8 -353 | n | % | n | % | ||
Genoypes | ||||||
AA | 47 | 26.7 | 59 | 22.4 | 0.3 | |
AT | 69 | 39.2 | 130 | 49.4 | 0.03 | 0.66 (0.44–0.99) |
TT | 60 | 34.1 | 74 | 28.2 | 0.2 | |
Alleles | ||||||
A | 163 | 46.3 | 248 | 47.2 | ||
T | 189 | 53.7 | 278 | 52.8 | 0.8 | |
IL-8 +781 | n | % | n | % | ||
Genotypes | ||||||
CC | 74 | 39.6 | 99 | 35.3 | 0.3 | |
CT | 85 | 45.4 | 151 | 54 | 0.07 | |
TT | 28 | 15 | 30 | 10.7 | 0.2 | |
Alleles | ||||||
C | 233 | 62.3 | 349 | 62.3 | ||
T | 141 | 37.7 | 211 | 37.7 | 0.9 | |
IL8 -353T/+781C | ||||||
Haplotypes | ||||||
-353T/+781C | 15 | 5.7 | 39 | 10 | 0.05 | 0.55 (0.21–8.05) |
-353T/+781T | 104 | 39.7 | 149 | 38.2 | 0.7 | |
-353A/+781C | 140 | 53.4 | 193 | 49.5 | 0.3 | |
-353A/+781T | 3 | 1.2 | 9 | 2.3 | 0.3 | |
IL-1α -889 | ||||||
Genotypes | ||||||
CC | 72 | 49.3 | 138 | 50.9 | 0.7 | |
CT | 59 | 40.4 | 115 | 42.4 | 0.7 | |
TT | 15 | 10.3 | 18 | 6.7 | 0.2 | |
Alleles | ||||||
C | 203 | 69.5 | 391 | 72.1 | ||
T | 89 | 30.5 | 151 | 27.9 | 0.4 | |
MCP-1 -2518 | ||||||
Genotypes | ||||||
AA | 86 | 54.4 | 170 | 58.2 | 0.4 | |
AG | 61 | 38.6 | 100 | 34.2 | 0.3 | |
GG | 11 | 7 | 22 | 7.5 | 0.8 | |
Alleles | ||||||
A | 233 | 73.7 | 440 | 75.3 | ||
G | 83 | 26.3 | 144 | 24.7 | 0.6 | |