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Table 4 Relationship between RANTES, IL-8, MCP-1 and IL-1α polymorphisms and the presence of nephritis in SLE Spanish patients.

From: Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus

  SLE with nephritis SLE without nephritis P OR (95%CI)
RANTES -403 n % n %   
Genotypes       
GG 136 73.5 230 73 0.9  
GA 44 23.8 71 22.5 0.7  
AA 5 2.7 14 4.4 0.3  
Alleles       
G 54 14.6 99 15.7   
A 316 85.4 531 84.3 0.6  
RANTES R3 n % n %   
Genotypes       
CC 89 77.4 225 68.8 0.08  
CT 23 20 92 28.1 0.1  
TT 3 2.6 10 3 0.8  
Alleles       
C 201 87.4 542 82.9   
T 29 12.6 112 12.1 0.1  
IL-8 -353 n % n %   
Genoypes       
AA 47 26.7 59 22.4 0.3  
AT 69 39.2 130 49.4 0.03 0.66 (0.44–0.99)
TT 60 34.1 74 28.2 0.2  
Alleles       
A 163 46.3 248 47.2   
T 189 53.7 278 52.8 0.8  
IL-8 +781 n % n %   
Genotypes       
CC 74 39.6 99 35.3 0.3  
CT 85 45.4 151 54 0.07  
TT 28 15 30 10.7 0.2  
Alleles       
C 233 62.3 349 62.3   
T 141 37.7 211 37.7 0.9  
IL8 -353T/+781C
Haplotypes       
-353T/+781C 15 5.7 39 10 0.05 0.55 (0.21–8.05)
-353T/+781T 104 39.7 149 38.2 0.7  
-353A/+781C 140 53.4 193 49.5 0.3  
-353A/+781T 3 1.2 9 2.3 0.3  
IL-1α -889       
Genotypes       
CC 72 49.3 138 50.9 0.7  
CT 59 40.4 115 42.4 0.7  
TT 15 10.3 18 6.7 0.2  
Alleles       
C 203 69.5 391 72.1   
T 89 30.5 151 27.9 0.4  
MCP-1 -2518
Genotypes       
AA 86 54.4 170 58.2 0.4  
AG 61 38.6 100 34.2 0.3  
GG 11 7 22 7.5 0.8  
Alleles       
A 233 73.7 440 75.3   
G 83 26.3 144 24.7 0.6