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Table 5 Analysis of associations between genotypes and phenotypes related with T2D in the C2 group.

From: Analysis of common PTPN1gene variants in type 2 diabetes, obesity and associated phenotypes in the French population

 

Genotypes

N

Go (mmol/l)*

Io (mSI/ml)

HOMA-B

HOMA-IR*

   

Mean

pdom prec

Mean

pdom prec

Mean

pdom prec

Mean

pdom prec

-7077G/C

GG

283

5.03 ± 0.37

0.41

5.02 ± 2.45

0.43

68.63 ± 35.42

0.14

1.13 ± 0.58

0.63

 

GC

336

5.05 ± 0.35

0.37

5.24 ± 4.81

0.13

66.44 ± 32.30

0.05

1.19 ± 1.11

0.16

 

CC

102

5.10 ± 0.34

 

4.57 ± 1.85

 

58.96 ± 25.34

 

1.04 ± 0.44

 

rs6020563

TT

186

5.05 ± 0.34

0.83

5.23 ± 2.52

0.05

69.98 ± 35.11

0.07

1.18 ± 0.60

0.08

 

TG

319

5.05 ± 0.36

0.98

5.17 ± 4.88

0.07

65.68 ± 31.96

0.1

1.17 ± 1.13

0.11

 

GG

150

5.06 ± 0.34

 

4.63 ± 1.89

 

61.23 ± 25.65

 

1.05 ± 0.47

 

rs941798

AA

223

5.08 ± 0.33

0.23

4.69 ± 1.93

0.15

61.23 ± 25.81

0.03

1.06 ± 0.46

0.31

 

AG

345

5.03 ± 0.37

0.85

5.23 ± 4.88

0.06

67.75 ± 35.89

0.075

1.18 ± 1.13

0.06

 

GG

153

5.05 ± 0.35

 

5.20 ± 2.24

 

70.15 ± 34.05

 

1.17 ± 0.54

 

rs2426159

AA

202

5.04 ± 0.35

0.64

5.21 ± 2.51

0.04

70.36 ± 37.00

0.05

1.18 ± 0.60

0.07

 

AG

360

5.05 ± 0.36

0.81

5.19 ± 4.71

0.06

66.71 ± 35.32

0.06

1.17 ± 1.09

0.15

 

GG

161

5.06 ± 0.35

 

4.66 ± 2.01

 

61.68 ± 26.88

 

1.05 ± 0.45

 

rs3787345

CC

261

5.03 ± 0.37

0.31

5.05 ± 2.49

0.55

69.12 ± 36.16

0.15

1.14 ± 0.59

0.82

 

CT

332

5.05 ± 0.34

0.18

5.06 ± 2.44

0.115

67.28 ± 35.07

0.03

1.14 ± 0.57

0.21

 

TT

116

5.10 ± 0.34

 

5.28 ± 7.38

 

59.37 ± 25.80

 

1.21 ± 1.70

 

rs6020608

CC

366

5.02 ± 0.38

0.17

4.95 ± 2.36

0.79

67.93 ± 34.04

0.12

1.12 ± 0.56

0.92

 

CT

291

5.06 ± 0.33

0.03

5.25 ± 5.08

0.79

65.54 ± 32.22

0.16

1.19 ± 1.17

0.99

 

TT

64

5.15 ± 0.33

 

4.80 ± 2.12

 

59.72 ± 59.72

 

1.10 ± 0.50

 

rs754118

CC

297

5.01 ± 0.38

0.05

4.97 ± 2.44

0.92

68.76 ± 35.38

0.09

1.12 ± 0.58

0.73

 

CT

314

5.07 ± 0.33

0.18

5.28 ± 4.93

0.36

65.67 ± 31.93

0.14

1.20 ± 1.14

0.5

 

TT

94

5.11 ± 0.34

 

4.71 ± 1.99

 

60.19 ± 26.53

 

1.08 ± 0.47

 

rs718050

GG

290

5.01 ± 0.38

0.09

5.03 ± 2.48

0.54

69.50 ± 35.55

0.05

1.13 ± 0.59

0.77

 

GA

324

5.06 ± 0.33

0.07

5.23 ± 4.86

0.30

65.79 ± 32.21

0.07

1.18 ± 1.13

0.48

 

AA

96

5.12 ± 0.34

 

4.65 ± 1.90

 

58.93 ± 24.56

 

1.06 ± 0.45

 
  1. Data are means ± SD for nonadjusted variables. Variables were transformed and adjusted by covariates (age, sex, BMI). The G0 and HOMA-IR variables had non-Gaussian residuals and were thus analysed by non-parametric tests as indicated by an asterisk (*); other variables were analysed by an ANOVA test. Results were presented for dominant and recessive models. Only SNPs showing an association were presented.
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BMC Medical Genetics

ISSN: 1471-2350

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