Table 2 Comparison of MMP9 haplotype frequency estimates in cases and controls and risk estimates from CLR analysis of matched case-control pairs. The haplotype configuration is as follows: Q279R, R574P, G607G and V694V.
haplotype | # controls | freq | # cases (TS) | freq | p-value | CLR:OR (95%CI) | # controls | freq | # cases(TT) | freq | p-value | CLR:OR (95%CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
ACCG | 450 | 0.34 | 466 | 0.36 | - | reference | 204 | 0.32 | 218 | 0.36 | - | reference |
ACAG | 298 | 0.22 | 303 | 0.23 | 0.845 | 0.98(0.80, 1.21) | 150 | 0.24 | 167 | 0.27 | 0.514 | 1.11 (0.82, 1.50) |
GCAA | 201 | 0.15 | 186 | 0.14 | 0.257 | 0.87 (0.69, 1.11) | 91 | 0.14 | 75 | 0.12 | 0.224 | 0.79 (0.54, 1.15) |
GCAG | 161 | 0.12 | 130 | 0.10 | 0.048 | 0.77 (0.59, 0.99) | 80 | 0.13 | 55 | 0.09 | 0.021 | 0.62 (0.41, 0.93) |
AGAG | 123 | 0.09 | 130 | 0.10 | 0.705 | 1.06 (0.79,1.40) | 61 | 0.10 | 55 | 0.09 | 0.451 | 0.85 (0.56, 1.30) |
AGCG | 66 | 0.05 | 55 | 0.04 | 0.204 | 0.78 (0.53, 1.15) | 33 | 0.05 | 27 | 0.04 | 0.171 | 0.66 (0.37, 1.20) |
GCCG | 30 | 0.02 | 32 | 0.02 | 0.977 | 0.99 (0.58, 1.68) | 13 | 0.02 | 17 | 0.03 | 0.604 | 1.24 (0.56, 2.75) |