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Table 4 Characteristics of studies on NAT2 polymorphisms and Parkinson's disease: genetic and disease-association analyses

From: N-acetyltransferase 2 (NAT2) gene polymorphisms in Parkinson's disease

Authors, country Samples NAT2 variants Assay Statistical analysis Slow acetylator PD cases (%) Slow acetylator controls (%) Association Yes/No
Van der Walt et al. 2003, USA blood 282, 341,481,590, 857 oligo ligation assay pedigree disequilibrium test (PDT-sum), likelihood ratio test (Transmit), χ2-test NG1 NG1 No overall, but marginal c.282 in EOPD
Bandmann et al. 2000, UK blood, brain tissue 191, 341,282,481,590, 803, 857 allele-specific CR, PCR-RFLP χ2-test, OR 95% CI, Yate's correction familial: 69.0 sporadic: 59.0 37.0 Yes
Bandmann et al. 1997, UK blood, brain tissue 481, 590, 857 PCR-RFLP χ2-test, OR 95% CI, Yate's correction familial: 73 sporadic: 60 39.0 Yes
Nicholl et al. 1999, UK blood 481, 282, 590, 803, few cases: 191, 857 PCR-RFLP χ2-test, two-sample t- or Wilcoxon tests, OR 95% CI familial: 53.3 sporadic: 60.1 familial: 76.7 sporadic: 55.4 No
Chaudhary et al. 2005, India blood 191, 282, 341,481, 590, 803, 857 PCR-RFLP χ2-test, PHASE 2.0.2 for haplotypes, OR 95% CI pooled: 19.2 EOPD: 25.78 LOPD: 12.29 pooled: 13.45 EOPD control: 13.01 LOPD control: 13.78 Yes, c.590 and c.857 in EOPD c.282 in LOPD
Chan et al. 2003, China blood 481,590,857 PCR-RFLP logistic regression analysis, adjusted OR 95% CI 68.7 28.6 Yes
Bialecka et al. 2002, Poland blood 481,590,803,857 PCR-RFLP χ2-test, OR 95% CI, Yate's correction 64.8 46.9 Yes
Maraganore et al. 2000, USA blood 481,590, 857 PCR-RFLP logistic regression analysis, adjusted OR 95% CI, two-sided p values 54.0 53.0 No overall, but c.857
Dupret et al. 1999, France blood 191,341,590,857 allele-specific PCR, PCR-RFLP NG1 51.5 59.8 No
Harhangi et al. 1999, Netherlands blood 481,590, 857 PCR-RFLP OR 95% CI, Fischer's exact test two tailed 54.0 53.0 No
Agundez et al. 1998, Spain blood 191, 282, 341, 590, 803, 857 PCR-RFLP χ2-test, OR 95% CI, Fischer's exact test EOPD: 78.4 LOPD: 54.8 55.4 No overall, but yes OEPD
  1. NG1=not given