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Table 2 Microsatellite markers demonstrating nominally significant (p ≤ 0.05) empiric p-values for allele and genotype frequency differences between dementia cases and controls. Microsatellite markers in close proximity to those demonstrating significance in this study and found to be either linked (lod ≥ 1) or associated (p ≤ 0.05) in previous studies are also listed.

From: Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish

Chromosome Map Position (cM) Mb Location Marker Fisher's Exact p-value Empiric p-value Max Lod Score Study
     Allele Genotype Allele Genotype   
1 25 11.4 D1S2667 0.162 0.007 0.170 0.015   
1 64 32.1 D1S396 0.043 0.449 0.050 0.407   
2 38 17.4 D2S1360 0.028 0.243 0.035 0.228   
2 74 50.7 D2S1352 0.200 0.026 0.208 0.032   
2 252 237.9 D2S2968 0.688 0.018 0.684 0.025   
3 119 103.7 D3S2459 0.223 0.007 0.231 0.014   
3 153 140.7 D3S1764 0.029 0.271 0.035 0.248   
3 177 168.7 D3S1763      1.69 Hahs et al.
3 201 187.5 D3S1602    0.007**    Hiltunen et al.
3 201 187.7 D3S1262 0.001 0.019 0.003 0.026   
3 209 191 D3S2398      2.16 Hahs et al.
3 216 193.8 D3S2418      1.18 Hahs et al.
4 78   D4S2367 0.557 0.015 0.557 0.022   
4 130 130.7 D4S2394      2.12 Hahs et al.
4 146 143.9 D4S1625 0.032 0.013 0.038 0.020   
4 154 152.5 D4S1548      3.01 Hahs et al.
4 158 158.7 D4S1629      1.32 Pericak-Vance et al. (2000)
5 8   D5S2849 0.590 0.031 0.589 0.038   
5 92 82.3 D5S1347 0.060 0.002 0.068 0.007   
5 98 89.2 D5S1725      1.47 Hahs et al.
5 147 144.1 D5S1480 0.465 0.001 0.467 0.005   
5 175 168.4 D5S400 0.04*      Farrer et al.
5 183 173.2 D5S211 0.001 0.001 0.002 0.004   
5 183 173.2 D5S211      1.3 Blacker et al.
6 89 77.5 D6S1031 0.024 0.046 0.030 0.051   
6 160 158 D6S1007 0.933 0.017 0.923 0.025   
8 60 32.2 D8S1477 0.004 0.018 0.007 0.026   
8 125 118.5 D8S592 0.387 0.032 0.391 0.038   
8 154 137.8 D8S272 0.007 0.021 0.010 0.028   
9 14   D9S2169 0.022 0.394 0.027 0.362   
10 63 35.3 D10S1208 0.013 0.247 0.018 0.231   
10 76 57.2 D10S1221 0.028 0.054 0.034 0.059   
12 78 66.2 D12S1294 0.220 0.045 0.228 0.050   
13 39 42.1 D13S325 0.027 0.070 0.033 0.072   
13 76 96.7 D13S892 0.040 0.224 0.047 0.210   
14 44 37.4 D14S306 0.020 0.104 0.026 0.103   
14 94 86.3 D14S612 0.016 0.166 0.021 0.156   
15 101 92.8 D15S816 0.046 0.158 0.053 0.150   
15 116 98.9 D15S87 0.031 0.083 0.037 0.084   
16 64 49.7 D16S3396 0.039 0.450 0.046 0.409   
16 130   D16S2621 0.227 0.036 0.235 0.042   
17 36 14.2 D17S921 0.024 0.026 0.030 0.032   
17 126 77.8 D17S928 0.024 0.201 0.029 0.186   
18 7 3.1 D18S481 0.017 0.006 0.022 0.013   
18 109   D18S1362 0.431 0.021 0.434 0.028   
19 21 6.1 D19S1034    0.013**    Hiltunen et al.
19 33 9.7 D19S586      2.06 Hahs et al.
19 36 12.2 D19S1165 0.002 0.066 0.004 0.069   
20 39 17.3 D20S470 0.027 0.206 0.033 0.191   
21 27 30.6 D21S1270 0.245 0.010 0.253 0.018   
  1. Bold denotes markers nominally significant (p ≤ 0.05) in both allele and genotype comparisions
  2. Italics highlights markers empirically significant at p ≤ 0.005
  3. *SAS software was used to measure significant differences in allele frequency between DAT cases and controls
  4. **Pearson's chi-square was calculated and then empirical significance was determined through examination of 1000 replicated datasets.