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Table 1 General characterization of C282Y homozygous probands at the time of diagnosis according to gender

From: A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload

  Males n = 32 Females n = 11 p*
Age (years) 51 ± 13 (29–75) 47 ± 11 (32–65) n.s.
Transferrin Saturation (%) 92 (87–97) 83 (75–92) n.s.
Ferritin (ng/ml) 2694 (2006–3383) 1353 (122–2584) n.s.
Total Body Iron Stores (g) 9.86 (8.19–11.54) 6.11 (3.21–9.02) 0.030
Total lymphocytes (×10 6 /ml) 1.91 (1.69–2.13) 2.30 (1.92–2.67) n.s.
Total CD4+ cells(×10 6 /ml) 0.98 (0.84–1.11) 1.09 (0.85–1.32) n.s.
Total CD8+ cells(×10 6 /ml) 0.35 (0.28–0.42) 0.48 (0.36–0.59) n.s.
  1. Parameters are expressed as mean (95% confidence intervals) except age, which is expressed as mean ± standard deviation (maximum – minimum values).
  2. Estimation of TBIS was obtained in 27 males and 9 females.
  3. *Statistically significant differences between groups (p) were tested using Student's T test.