Figure 4

Haploview analyses of CEPH and Yoruba Africans genotyped by the HapMap Consortium. Using the data and analyses available at the website, http://www.hapmap.org, we selected the genotypes for the CEPH and Yoruba populations. The CEPH LD plot, using Haploview is shown above the Yoruba plot (inverted). As can be seen, for both, there is little evidence of significant LD for the SNP makers used. Additionally, two hotspots for recombination were identified (depicted by the red bars at the bottom of the picture), located at the ends of the STSL locus and involve the terminal exons of both ABCG5 and ABCG8 (which contain the transmembrane domains).