Skip to main content

Table 3 Plasma renin activity and serum aldosterone concentration during postural and captopril challenge tests

From: Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension

  Carriers of the ENaC variants Non-carriers P-values
  βENaC i12-17CT βENaC G589S γENaC V546I All   All variants versus non-carriers
Postural test (n) 15 8 7 30 268  
PRA, supine 0.7 (0.4–1.7) 0.7 (0.4–1.0) 0.6 (0.3–1.8) 0.7 (0.4–1.2) 0.8 (0.5–1.4) 0.37
PRA, upright 1.2 (0.8–2.3) 1.5 (0.7–2.9) 1.6 (0.3–2.4) 1.5 (0.7–2.4) 1.9 (1.0–3.5) 0.11
Aldosterone, supine 343 (225–398) 457 (251–592) 358 (238–622) 368 (243–482) 369 (273–474) 0.76
Aldosterone, upright 663 (353–1073) 725 (552–960) 1036 (585–1643) 761 (484–1129) 939 (584–1255) 0.21
Captopril test (n) 15 8 8 31 282  
PRA, 0 min 1.2 (0.8–2.4) 1.3 (0.5–2.9) 1.3 (0.2–3.4) 1.2 (0.6–2.6) 1.4 (0.7–2.5) 0.53
PRA, 60 min 1.7 (1.0–6.2) 3.0 (0.5–5.7) 2.3 (0.5–8.2) 1.9 (0.8–5.7) 3.6 (1.3–7.7) 0.12
Aldosterone, 0min 554 (302–820) 608 (474–806) 645 (361–1312) 599 (340–845) 618 (431–877) 0.47
Aldosterone, 60min 400 (245–513) 400 (336–472) 356 (261–803) 392 (250–513) 397 (311–539) 0.41
  1. Data is given as median (interquartile range). PRA, plasma renin activity (μg/L/h); Aldosterone, serum aldosterone concentration (pmol/L). Reference values: renin 0.9–2.0 (supine) and 2.0–5.0 (upright), and aldosterone 85–470 (supine) and 220–1000 (upright).