| |
Carriers of the ENaC variants
|
Non-carriers
|
P-values
|
|---|
| |
βENaC i12-17CT
|
βENaC G589S
|
γENaC V546I
|
All
| |
All variants versus non-carriers
|
|---|
|
Postural test (n)
|
15
|
8
|
7
|
30
|
268
| |
|
PRA, supine
|
0.7 (0.4–1.7)
|
0.7 (0.4–1.0)
|
0.6 (0.3–1.8)
|
0.7 (0.4–1.2)
|
0.8 (0.5–1.4)
|
0.37
|
|
PRA, upright
|
1.2 (0.8–2.3)
|
1.5 (0.7–2.9)
|
1.6 (0.3–2.4)
|
1.5 (0.7–2.4)
|
1.9 (1.0–3.5)
|
0.11
|
|
Aldosterone, supine
|
343 (225–398)
|
457 (251–592)
|
358 (238–622)
|
368 (243–482)
|
369 (273–474)
|
0.76
|
|
Aldosterone, upright
|
663 (353–1073)
|
725 (552–960)
|
1036 (585–1643)
|
761 (484–1129)
|
939 (584–1255)
|
0.21
|
|
Captopril test (n)
|
15
|
8
|
8
|
31
|
282
| |
|
PRA, 0 min
|
1.2 (0.8–2.4)
|
1.3 (0.5–2.9)
|
1.3 (0.2–3.4)
|
1.2 (0.6–2.6)
|
1.4 (0.7–2.5)
|
0.53
|
|
PRA, 60 min
|
1.7 (1.0–6.2)
|
3.0 (0.5–5.7)
|
2.3 (0.5–8.2)
|
1.9 (0.8–5.7)
|
3.6 (1.3–7.7)
|
0.12
|
|
Aldosterone, 0min
|
554 (302–820)
|
608 (474–806)
|
645 (361–1312)
|
599 (340–845)
|
618 (431–877)
|
0.47
|
|
Aldosterone, 60min
|
400 (245–513)
|
400 (336–472)
|
356 (261–803)
|
392 (250–513)
|
397 (311–539)
|
0.41
|
- Data is given as median (interquartile range). PRA, plasma renin activity (μg/L/h); Aldosterone, serum aldosterone concentration (pmol/L). Reference values: renin 0.9–2.0 (supine) and 2.0–5.0 (upright), and aldosterone 85–470 (supine) and 220–1000 (upright).
