Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension

Table 3 Plasma renin activity and serum aldosterone concentration during postural and captopril challenge tests

	Carriers of the ENaC variants				Non-carriers	P-values
	βENaC i12-17CT	βENaC G589S	γENaC V546I	All		All variants versus non-carriers
Postural test (n)	15	8	7	30	268
PRA, supine	0.7 (0.4–1.7)	0.7 (0.4–1.0)	0.6 (0.3–1.8)	0.7 (0.4–1.2)	0.8 (0.5–1.4)	0.37
PRA, upright	1.2 (0.8–2.3)	1.5 (0.7–2.9)	1.6 (0.3–2.4)	1.5 (0.7–2.4)	1.9 (1.0–3.5)	0.11
Aldosterone, supine	343 (225–398)	457 (251–592)	358 (238–622)	368 (243–482)	369 (273–474)	0.76
Aldosterone, upright	663 (353–1073)	725 (552–960)	1036 (585–1643)	761 (484–1129)	939 (584–1255)	0.21
Captopril test (n)	15	8	8	31	282
PRA, 0 min	1.2 (0.8–2.4)	1.3 (0.5–2.9)	1.3 (0.2–3.4)	1.2 (0.6–2.6)	1.4 (0.7–2.5)	0.53
PRA, 60 min	1.7 (1.0–6.2)	3.0 (0.5–5.7)	2.3 (0.5–8.2)	1.9 (0.8–5.7)	3.6 (1.3–7.7)	0.12
Aldosterone, 0min	554 (302–820)	608 (474–806)	645 (361–1312)	599 (340–845)	618 (431–877)	0.47
Aldosterone, 60min	400 (245–513)	400 (336–472)	356 (261–803)	392 (250–513)	397 (311–539)	0.41

Data is given as median (interquartile range). PRA, plasma renin activity (μg/L/h); Aldosterone, serum aldosterone concentration (pmol/L). Reference values: renin 0.9–2.0 (supine) and 2.0–5.0 (upright), and aldosterone 85–470 (supine) and 220–1000 (upright).

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