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Table 1 β and γ ENaC variants identified among the three study groups

From: Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension

  Hypertension n (%) Normotensive males n (%) Blood donors n (%) Adjusted OR (95% CI)1
All variants 32 (9.2) 5 (2.9)** 9 (3.0)** 3.1 (1.6–6.0)
βENaC i12-17CT 16 (4.6) 2 (1.1)* 3 (1.0)** 4.6 (1.6–13.0)
βENaC G589S 8 (2.3) 2 (1.1) 3 (1.0) 2.4 (0.77–7.7)
γENaC V546I 8 (2.3) 1 (0.6) 3 (1.0) 2.2 (0.63–7.5)
Non-carriers 315 (90.8) 170 (97.1) 292 (97.0)  
  1. *P<0.05 and **P<0.01 vs. Hypertension group.
  2. 1OR for hypertension (versus combined control groups) in ENaC variant carriers vs. non-carriers, adjusted for age and gender.