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Table 1 Clinical characteristics of patients from trial ALL-BFM 2000

From: Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population

  Patients ALL-BFM 2000 (n = 443)
  Number of subjects (%)
Gender  
Male 268 (60.5)
Female 175 (39.5)
Age at diagnosis (years)  
< 1 -
1-< 6 264 (59.6)
6-< 10 80 (18.1)
≥ 10 99 (22.3)
DNA indexa  
< 1.16 258 (58.2)
≥ 1.16 48 (10.8)
no result 137 (30.9)
TEL/AML1 pos. 90 (20.3)
neg. 313 (70.7)
unknown 40 (9.0)
BCR/ABL pos. 9 (2.0)
neg. 412 (93.0)
unknown 22 (5.0)
MLL/AF4 pos. 1 (0.2)
neg. 394 (88.9)
unknown 48 (9.9)
Immunophenotype  
Precursor B 344 (77.7)
T 81 (18.3)
Bipenotypic 4 (0.9)
Unknown 14 (3.2)
  1. aRatio of DNA content of leukemic G0/G1 cells to normal diploid lymphocytes.