Implication of the Pro12Ala polymorphism of the PPAR-gamma 2gene in type 2 diabetes and obesity in the French population

Table 4 Biochemical parameters of subjects according to Pro12Ala genotypes.

Populations	Genotypes	Fasting insulin (UI/l)	Fasting glucose (mmol/l)	Body Mass Index (Kg/m²)	Z score of BMI	HOMA-IR	HOMA-B
NGT non obese adults (n = 865)	P/P = 673	6.28 ± 0.24	4.92 ± 0.02	23.61 ± 0.14	-	1.39 ± 0.05	92.99 ± 3.44
	P/A+AA = 192	6.23 ± 0.31	4.94 ± 0.03	24.02 ± 0.26	-	1.38 ± 0.07	95.11 ± 7.19
	P-value	0.92	0.65	0.16	-	0.90	0.78
NGT non obese children (n = 362)	P/P = 291	5.39 ± 0.17	4.70 ± 0.21	18.12 ± 0.15	- 0.24 ± 0.06	1.13 ± 0.04	95.84 ± 3.47
	P/A+AA = 71	6.21 ± 0.42	4.71 ± 0.04	18.19 ± 0.28	- 0.27 ± 0.12	1.315 ± 0.09	111.58 ± 9.62
	P-value	0.06	0.67	0.84	0.84	0.06	0.62
NGT obese adults (n = 507)	P/P = 397	14.35 ± 0.60	5.30 ± 0.02	40.82 ± 0.42	-	3.41 ± 0.15	171.07 ± 7.60
	P/A+AA = 110	11.93 ± 0.72	5.19 ± 0.05	40.08 ± 0.70	-	2.75 ± 0.16	165.89 ± 17.31
	P-value	0.01	0.04	0.40	-	0.003	0.76
NGT obese children (n = 525)	P/P = 402	12.00 ± 0.59	4.90 ± 0.22	27.92 ± 0.30	4.06 ± 0.06	2.659 ± 0.14	178.71 ± 8.66
	P/A+AA = 123	10.77 ± 0.74	4.89 ± 0.42	28.55 ± 0.62	4.20 ± 0.14	2.368 ± 0.16	169.31 ± 16.48
	P-value	0.18	0.61	0.33	0.37	0.18	0.37

Data are given as mean ± mean standard error. Quantitative traits are shown according to the Pro12Ala genotypes in healthy and NGT obese French populations under a dominant model. Z score of BMI was used rather than BMI in children. Quantitative traits were studied using a general linear model procedure, taking into account gender, age, BMI and genotype effect. BMI was adjusted only by gender and age. Z score of BMI was compared according to the Pro12Ala genotypes using the T-test. Pro allele is indicated as P and Ala allele as A.

ISSN: 1471-2350