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Table 5 Allele average effects αS, αM and αL estimated for S, M and L alleles respectively of the 3'VNTR-APOB polymorphism in the whole sample of healthy subjects after normalization for age, sex and BMI (computed according to the formula: BMI = weight [Kg]/ height [m2])

From: A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians

  αS 95% c.i. αS αM 95% c.i. αM αL 95% c.i. αL
TC -5.98 -11.62 ÷ -0.74 +1.67 -0.28 ÷ +3.90 +0.93 -6.20 ÷ +8.13
HDL-C -0.09 -2.01 ÷ +1.71 -0.08 -0.64 ÷ +0.81 +0.26 -2.51 ÷ +2.30
LDL-C -4.41 -8.93 ÷ -0.20 +1.28 -0.65 ÷ +3.10 +0.45 -5.70 ÷ +6.82
TG (Log10) +0.01 -0.02 ÷ +0.03 0.00 -0.01 ÷ +0.01 -0.01 -0.04 ÷ +0.02
  1. TC: serum Total Cholesterol; HDL-C: serum HDL-Cholesterol; LDL-C: serum LDL-Cholesterol; TG: serum Tryglycerides. Average effects are expressed in mg/dL. Confidence intervals (c.i.) are computed by bootstrap (1,000 replications).
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BMC Medical Genetics

ISSN: 1471-2350

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