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Table 5 Families showing slight evidence for linkage of myopia (Model 1) to chromosome 12q or 18p

From: Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia

AMISH FAMILIES
FAMILY ID TWO-POINT LOD MULTIPOINT
  Marker Zmax LOD NPL P value
3061 D12S1706 1.04 1.04 * N/A
  D12S346 1.04 1.04 * N/A
  D12S78 1.04 1.04 * N/A
3049 D18S474 1.14 1.27 2.19 0.02
3053 D18S474 1.30 1.30 -* N/A
3064 D18S63 1.30 1.30 -* N/A
JEWISH FAMILIES
FAMILY ID TWO-POINT LOD MULTIPOINT
  Marker Zmax LOD NPL P value
20 D12S79 1.12 1.12 3.45 0.02
  D12S86 1.12 1.12 3.45 0.02
58 D12S1706 1.16 1.16 3.01 0.06
  D12S346 1.16 1.16 3.01 0.06
78 D12S85 1.07 1.07 3.38 0.01
  1. * Only single affected parent-offspring pairs were genotyped in these families so the NPL analysis was uninformative in these families. However, the parametric LOD score analysis that uses both affected and unaffected family members was informative for linkage.