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Table 5 Families showing slight evidence for linkage of myopia (Model 1) to chromosome 12q or 18p

From: Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia

AMISH FAMILIES

FAMILY ID

TWO-POINT LOD

MULTIPOINT

 

Marker

Zmax

LOD

NPL

P value

3061

D12S1706

1.04

1.04

*

N/A

 

D12S346

1.04

1.04

*

N/A

 

D12S78

1.04

1.04

*

N/A

3049

D18S474

1.14

1.27

2.19

0.02

3053

D18S474

1.30

1.30

-*

N/A

3064

D18S63

1.30

1.30

-*

N/A

JEWISH FAMILIES

FAMILY ID

TWO-POINT LOD

MULTIPOINT

 

Marker

Zmax

LOD

NPL

P value

20

D12S79

1.12

1.12

3.45

0.02

 

D12S86

1.12

1.12

3.45

0.02

58

D12S1706

1.16

1.16

3.01

0.06

 

D12S346

1.16

1.16

3.01

0.06

78

D12S85

1.07

1.07

3.38

0.01

  1. * Only single affected parent-offspring pairs were genotyped in these families so the NPL analysis was uninformative in these families. However, the parametric LOD score analysis that uses both affected and unaffected family members was informative for linkage.
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BMC Medical Genetics

ISSN: 1471-2350

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