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Table 2 Power and ELods from 100 replicates of simulated data, dominant susceptibility allele frequency of 0.01

From: Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia

PENETRANCE IN DD:Dd SUSC. ALLELE CARRIERS PENETRANCE IN dd NORMAL HOMOZYGOTE % FAMILIES LINKED
   100% 75% 50% 25%
   Power1 ELod ± s.d.2 Power1 ELod ± s.d.2 Power1 ELod ± s.d.2 Power1 ELod ± s.d.2
0.8 0.08 100 14.0 ± 0.3 99 8.9 ± 0.3 82 4.7 ± 0.2 18 1.7 ± 0.1
0.8 0.15 100 14.7 ± 0.3 100 9.1 ± 0.3 73 4.8 ± 0.2 14 1.6 ± 0.1
0.7 0.08 100 14.8 ± 0.3 99 8.5 ± 0.3 77 4.8 ± 0.2 17 1.8 ± 0.15
0.7 0.15 100 15.2 ± 0.3 99 8.8 ± 0.3 70 4.5 ± 0.2 14 1.6 ± 0.1
0.6 0.08 100 15.0 ± 0.3 98 8.6 ± 0.25 67 4.3 ± 0.2 14 1.7 ± 0.1
0.6 0.15 100 14.2 ± 0.3 100 8.4 ± 0.3 73 4.3 ± 0.2 5 1.2 ± 0.1
  1. 1Power = 100 X Proportion of replicate samples that yielded a homogeneity LOD score ≥ 3.0 2ELod = average homogeneity LOD score over all replicates ± its standard deviation