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Table 7 CVID and IgGSD Index Cases Positive for Haplotype A*01-B*08.1

From: HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama

Serum Immunoglobulin Concentrations Total IgG Concentration, frequency in 195 Index Cases (fraction) IgA Concentration, frequency in 195 Index Cases (fraction) IgM Concentration, frequency in 195 Index Cases (fraction)
No Deficiency2 0.23 (23/100) 0.24 (39/162) 0.24 (41/169)
Deficiency2 0.27 (26/95) 0.30 (10/33) 0.31 (8/26)
  1. 1 Comparisons of positivity for HLA haplotype A*01-B*08 revealed no significant differences (Chi-square analysis) in index cases grouped by serum total IgG, IgA, and IgM concentration, respectively. 2 Deficiency of an immunoglobulin class was defined by a serum concentration at diagnosis that was less than the corresponding lower reference limit.