Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations

BMC Medical Genetics

Table 4 Genes with increased and decreased levels of expression in at least 15 of 20 comparisonsbetween 4 mutant MeCP2 expressing LCLs and 5 wild type MeCP2 expressing LCLs

INCREASED
GenBank Accession	Expression In Brain	Gene Symbol/UniGene No.	Gene Name	Function
X15306	x	NF-H	Neurofilament H	intermediate filament
J03600	x	ALOX5	Arachidonate 5-lipoxygenase	synthesis of leukotrienes
M38690		CD9	CD9 antigen (p24)	transmembrane protein
J04076	x	EGR2	Early growth response 2	transcription factor
AA873858	x	H2BFD	H2B histone family, member D	compaction of DNA
M81750		MNDA	Myeloid cell nuclear differentiation antigen	cell specific response to interferon
S81914		IER3	Immediate early response 3	inhibits apoptosis
M33197	x	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	carbohydrate metabolism
AI761588		Hs.359719
AF052145	x	Hs.159528
AB020695	x	Hs.91662
DECREASED
GenBank Accession	Expression In Brain	Gene Symbol/UniGene No.	Gene Name	Function
L08177		EBI2	Epstein-Barr virus induced gene 2	G-protein coupled receptor
AW026672		TXNIP	Thioredoxin interacting protein	upregulated by 1,25-dihydroxyvitamin D-3
AI239716		Hs.344976	Chloride intracellular channel 2 protein^a	anion transport
AI290954	x	Hs.110080	Alpha-2-macroglobin^a	cell growth
AI431931	x	Hs.128797