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Table I Results of triple color FISH reactions with probes for 7q31, hTERT and hTR given as the average number of signals per cell in each sample tested.

From: Telomerase activity in human leukemic cells with or without monosomy 7 or 7q-

3q (hTERC)

3q (hTERC)

5p (hTERT)

5p (hTERT)

7q (D7S486)

7q (D7S486)

7q (D7S522

7q (D7S522)

7q deletion

no 7q delet

7q deletion

no 7q delet

7q deletion

no 7q delet

7q deletion

no 7q delet

1,83

1,95

1,95

1,98

1,41

1,95

1,40

1,97

1,92

1,96

1,80

1,96

1,83

1,94

1,81

1,95

1,86

1,92

1,93

1,88

1,38

1,96

1,52

1,93

1,82

1,88

1,85

1,80

1,85

1,97

1,79

1,97

1,96

1,94

1,84

1,97

1,48

1,96

1,42

1,96

1,88

1,88

1,82

1,94

1,42

1,94

1,40

1,94

1,86

1,94

1,78

1,94

1,68

1,98

1,66

1,98

1,94

1,93

1,90

1,94

1,62

1,95

1,40

1,95

1,87

1,82

1,95

1,89

1,79

2,00

1,75

2,00

1,52

1,70

1,83

1,84

1,81

1,97

1,80

1,97

1,89

1,95

1,91

1,99

1,19

1,96

1,44

1,96

1,92

1,97

1,93

2,00

1,74

1,98

1,73

1,98

1,90

1,93

1,82

1,93

1,49

1,96

1,49

1,96

1,81

1,95

1,90

1,84

1,57

1,91

1,55

1,91

1,85

1,85

1,85

1,97

1,78

1,97

1,82

1,97

1,65

1,94

1,82

1,92

1,42

1,95

1,38

1,94

1,45

1,82

1,88

1,81

1,66

1,97

1,69

1,95

  1. Signal frequencies were generally in the 1.8–2.0 range, except that the 7q- samples showed the expected reduction in signal frequency with the 7q31 probes. For the hTR and hTERT probes the frequencies never exceeded 2.0, nor did we observe signals that were enhanced in intensity. In fact, some samples instead showed deletion of one of the genes in a fraction of cells.