Population | Studies | OR | IC (95%) | P | PQ | I2(%) | |
---|---|---|---|---|---|---|---|
4b/a | |||||||
Allele contrast | All | 15 | 1.15 | 1.05-1,25 | <0.01 | <0.01 | 66 |
African | 2 | 0,98 | 0.81-1.18 | 0.88 | 0,25 | 22 | |
East Asians | 6 | 1.21 | 0.97-1.50.8 | 0.08 | 0.29 | 18 | |
Whites | 7 | 1.20 | 1.07-1.34 | <0.01 | <0.01 | 80 | |
Type 1 | 5 | 1.17 | 1.02-1.34 | 0.02 | 0.07 | 54 | |
Type 2 | 10 | 1.12 | 0.99-1.27 | 0.07 | 0.28 | 18 | |
Additive | All | 15 | 1.52 | 1.18-1.97 | <0.01 | <0.01 | 62 |
African | 2 | 1,13 | 0,69-1,81 | 0.62 | 0.56 | 0 | |
East Asians | 6 | 3.25 | 1.58-6.68 | <0.01 | 0.31 | 16 | |
Whites | 7 | 1.49 | 1.06-2.08 | 0.01 | <0.01 | 74 | |
Type 1 | 5 | 2.21 | 1.50-3.25 | <0.01 | <0.01 | 81 | |
Type 2 | 11 | 1.36 | 0.98-1.88 | 0.06 | 0.08 | 41 | |
Recessive | All | 15 | 1.50 | 1.16-1.93 | <0.01 | <0.01 | 64 |
Africans | 2 | 1.13 | 0.69-1.83 | 0,61 | 0.83 | 0 | |
East Asians | 6 | 3.44 | 1.68-7.05 | <0.01 | 0.28 | 21 | |
Whites | 7 | 1.43 | 1.03-1.99 | 0.03 | <0.01 | 75 | |
Type 1 | 5 | 2.19 | 1.49-3.21 | <0.01 | <0.01 | 81 | |
Type 2 | 11 | 1.49 | 1.07-2.07 | 0.02 | 0.08 | 42 | |
Dominant | All | 15 | 1.11 | 1.01-1.23 | 0.03 | 0,01 | 49 |
African | 2 | 0.94 | 0.75-1.18 | 0.64 | 0.24 | 27 | |
East Asians | 6 | 1.04 | 0.81-1.34 | 0.71 | 0.44 | 0 | |
Whites | 7 | 1.20 | 1.05-1.36 | <0.01 | <0.01 | 67 | |
Type 1 | 5 | 1.22 | 1.04-1.43 | 0.01 | <0.01 | 78 | |
Type 2 | 11 | 1.05 | 0.92-1.20 | 0.44 | 0.62 | 0 | |
Codominant | All | 15 | 0.98 | 0.88-1.09 | 0.81 | 0,02 | 46 |
African | 2 | 1.09 | 0.87-1.38 | 0.42 | 0.29 | 7 | |
East Asians | 6 | 1.17 | 0.90-1.55 | 0.22 | 0.14 | 38 | |
Whites | 7 | 0.90 | 0.79-1.04 | 0.16 | 0.04 | 54 | |
Type 1 | 5 | 0.94 | 0.80-1.11 | 0.46 | 0.01 | 68 | |
Type 2 | 11 | 1.01 | 0.88-1.17 | 0.80 | 0.19 | 26 | |
T-786C | |||||||
Allele contrast | All | 5 | 1.28 | 1.14-1.44 | <0.01 | 0.25 | 24 |
African | 2 | 1.44 | 1.21-1.71 | <0.01 | 0.26 | 19 | |
Whites | 2 | 1.13 | 0.94-1.36 | 0.19 | 0.44 | 0 | |
Type 2 | 4 | 1.29 | 1.13-1.46 | <0.01 | 0.15 | 42 | |
Additive | All | 5 | 1.48 | 1.14-1.92 | <0,01 | 0.01 | 67 |
African | 2 | 1.43 | 0.98-2.09 | 0.05 | 0.01 | 84 | |
Whites | 2 | 1.36 | 0.93-1.98 | 0.10 | 0.18 | 42 | |
Type 2 | 4 | 1.40 | 1.06-1.86 | 0.01 | <0.01 | 73 | |
Recessive | All | 5 | 1.38 | 1,09-1.76 | <0,01 | 0.01 | 68 |
African | 2 | 1.24 | 0.88-1.76 | 0.21 | 0.01 | 81 | |
Whites | 2 | 1.39 | 0.98-1.95 | 0.06 | 0.09 | 0 | |
Type 2 | 4 | 1.27 | 0.98-1.65 | 0.06 | 0.01 | 72 | |
Dominant | All | 5 | 1.21 | 1,04-1.42 | 0.01 | 0.29 | 18 |
African | 2 | 1.39 | 1.11-1.73 | <0.01 | 0.13 | 54 | |
Whites | 2 | 1.05 | 0.81-1.37 | 0.70 | 0.95 | 0 | |
Type 2 | 4 | 1.24 | 1.05-1.47 | <0.01 | 0.22 | 31 | |
Codominant | All | 5 | 0.95 | 0.81-1.11 | 0.53 | 0.12 | 45 |
African | 2 | 0.78 | 0.62-0.98 | 0.03 | 0.48 | 0 | |
Whites | 2 | 1.15 | 0.89-1.49 | 0.28 | 0.24 | 25 | |
Type 2 | 3 | 0.90 | 0.75-1.06 | 0.20 | 0.131 | 15 | |
G986T | |||||||
Allele contrast | All | 12 | 1.12 | 1.03-1.21 | <0.01 | <0.01 | 75 |
African | 3 | 1.63 | 1.39-1.91 | <0.01 | 0.61 | 0 | |
East Asian | 3 | 1.33 | 1.05-1.70 | 0.01 | 0.74 | 0 | |
Whites | 4 | 0.93 | 0.84-1.04 | 0.20 | 0.67 | 0 | |
Type 1 | 2 | 0.92 | 0.80-1.04 | 0.18 | 0.18 | 0 | |
Type 2 | 9 | 1.27 | 1.15-1.42 | <0.01 | <0.01 | 72 | |
Additive | All | 12 | 1.19 | 0.99-1.43 | 0.05 | <0.01 | 63 |
African | 3 | 2.01 | 1.50-2.94 | <0.01 | 0.27 | 22 | |
East Asian | 3 | 1.85 | 1,05-3.25 | 0.03 | 0.59 | 0 | |
Whites | 4 | 0.86 | 0.67-1.10 | 0.23 | 0.69 | 0 | |
Type 1 | 2 | 0.87 | 0.65-1.16 | 0.34 | 0.44 | 0 | |
Type 2 | 9 | 1.47 | 1.16-1.86 | <0.01 | <0.01 | 63 | |
Recessive | All | 12 | 1.16 | 0.97-1.38 | 0.09 | 0.02 | 52 |
Africa | 3 | 1.80 | 1.31-2.46 | <0.01 | 0.43 | 0 | |
East Asian | 3 | 1.73 | 1.01-2.96 | 0.04 | 0.63 | 0 | |
Whites | 4 | 0.88 | 0.69-1.11 | 0.29 | 0.62 | 0 | |
Type 1 | 2 | 0.91 | 0.69-1.20 | 0.49 | 0.31 | 0 | |
Type 2 | 9 | 1.36 | 1.08-1.70 | <0.01 | 0.03 | 53 | |
Dominant | All | 12 | 0.99 | 0.89-1.11 | 0.92 | 0.07 | 45 |
African | 3 | 1.46 | 1.17-1.82 | <0.01 | 0.11 | 54 | |
East Asian | 3 | 1.32 | 0.98-1.79 | 0.06 | 0.73 | 0 | |
Whites | 4 | 0.93 | 0.80-1.07 | 0.31 | 0.59 | 0 | |
Type 1 | 2 | 0.89 | 0.75-1.06 | 0.19 | 0.74 | 0 | |
Type 2 | 9 | 1.19 | 0.92-1.26 | 0.35 | 0.04 | 57 | |
Codominant | All | 12 | 1.03 | 1.04-1.37 | 0.01 | 0.01 | 60 |
African | 3 | 0.92 | 0.74-1.14 | 0.45 | 0.29 | 18 | |
East Asian | 3 | 0.89 | 0.65-1.21 | 0.48 | 0.52 | 0 | |
Whites | 4 | 1.02 | 0.89-1.18 | 0.69 | 0.44 | 0 | |
Type 1 | 2 | 1.08 | 0.91-1.29 | 0.35 | 0.32 | 0 | |
Type 2 | 9 | 0.94 | 0.82-1.08 | 0.41 | 0.34 | 11 |