Endothelial nitric oxide synthase gene polymorphisms and risk of diabetic nephropathy: a systematic review and meta-analysis

Dellamea, Bruno Schmidt; Pinto, Lana Catani Ferreira; Leitão, Cristiane Bauermann; Santos, Katia Gonçalves; Canani, Luis Henrique Santos

doi:10.1186/1471-2350-15-9

Table 2 Polymorphisms distribution

From: Endothelial nitric oxide synthase gene polymorphisms and risk of diabetic nephropathy: a systematic review and meta-analysis

Author	Distribution of the T-786C polymorphism						HWE
Author	Cases			Controls			p value
	TT	TC	CC	TT	TC	CC
Ahluwalia et al. [21]	121	62	12	165	87	3	0.020
Ezzidi et al. [10]	261	215	34	224	139	32	0.115
Santos et al. 2011 [29]	140	160	76	93	104	44	0.138
Shoukry et al. 2012 [32]	57	89	54	84	83	33	0.129
Zanchi et al. [17]	57	65	30	75	100	20	0.123
	Distribution of the G894T polymorphism						HWE
	Cases			Controls			p value
	GG	GT	TT	GG	GT	TT
Ahluwalia et al. [21]	82	81	32	125	105	25	0.658
Bessa et al. 2011 [22]	10	18	12	17	19	4	1.000
Cai et al. [23]	65	44	7	148	109	27	0.310
Ezzidi et al. [10]	185	247	81	165	195	41	0.151
Mollsten et al. [34]	492	365	89	268	232	51	0.919
Mollsten et al. [18]	293	133	32	182	121	16	0.540
Rahimi et al. 2012 [27]	68	45	13	39	17	7	0.038
Santos et al. 2011 [29]	176	166	32	118	95	22	0.640
Shin Shin et al. [31]	95	23	0	52	7	0	1.000
Shoukry et al. 2012 [32]	66	94	40	99	77	24	0.140
Tamemoto et al. [33]	104	18	2	181	27	3	0.117
Tiwari et al. [19]	82	21	3	91	43	13	0.035
	Distribution of the 4b/4a polymorphism						HWE
	Cases			Controls			p value
	bb	ba	aa	bb	ba	aa
Ahluwalia et al. [21]	146	28	21	189	61	5	1.000
Degen et al. [24]	229	94	4	297	105	9	1.000
Ezzidi et al. [10]	314	162	29	234	143	21	1.000
Fujita et al. [25]	81	21	0	55	10	0	1.000
Ksiasek et al. 2003 [13]	105	58	15	147	66	19	0.007
Lin et al. [26]	115	21	1	41	6	1	0.271
Mollsten et al. [34]	656	248	39	389	145	19	0.220
Neugebauer et al. [14]	101	26	6	71	10	1	0.351
Rippin et al. [28]	344	108	12	297	90	9	0.519
Santos et al. 2011 [29]	237	99	11	168	59	5	1.000
Shestakova et al. [16]	14	48	1	34	31	1	0.052
Shimizu et al. [30]	180	44	6	156	44	3	1.000
Shoukry et al. 2012 [32]	124	64	12	131	60	9	0.502
Taniwaki et al. [20]	63	21	2	50	19	0	0.340
Zanchi et al. [17]	80	27	37	144	47	4	1.000

HWE (Hardy-Weinberg equilibrium).

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