Genetic similarities between tobacco use disorder and related comorbidities: an exploratory study

BMC Medical Genetics

Table 2 Disorders associated to genes influencing tobacco use disorder selected from methods 1 and 2

Disorder	Method 1	Method 2
Addiction	X	X
Alcoholism	X	X
Bladder cancer	X	X
Cervical cancer		X
Coronary disease	X	X
Delirium	X
Depressive disorder	X	X
Dyskinesia	X
Gastric cancer	X	X
Gastrointestinal tract cancer		X
Hypertension		X
Insomnia	X
Leukaemia		X
Liver cancer		X
Malignant hypertension	X	X
Mood disorders	X
Movement disorders	X
Motor dysfunction	X	X
Oesophageal cancer	X	X
Pancreatic cancer		X
Psychomotor agitation	X	X
Schizophrenia	X	X
Schizoaffective disorder	X	X
Stroke	X	X
Subarachnoid haemorrhage	X
Vascular disorder	X	X

Method 1, 20 disorders with the strongest p-value indicating the relationship with the selected genes using Ingenuity Pathway Analysis; Method 2, based on category of disorders and developed in two steps: Firstly selection of the five disorders with the strongest p-value for each category and secondly limitation to the 20 disorders with the strongest p-value; Final selected disorders are the one retrieved from both method 1 and method 2.

ISSN: 1471-2350