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Table 2 Results of mutation analyser web-based tools

From: A novel insertion mutation identified in exon 10 of the MEFV gene associated with Familial Mediterranean Fever

  Computational pathogenicity predictions
  Prediction Score 1 Score 2 Score 1&2 description
http://agvgd.iarc.fr/agvgd_input.php[8, 9] Class C65 0.0 68.20 (GV, GD) Prediction ranges from C0-benign to C65- pathogenic
http://genetics.bwh.harvard.edu/pph2/ (HumVar Prediction) [10] Benign 0.265   
http://genetics.bwh.harvard.edu/pph2/ (HumDiv Prediction) [10] Possibly damaging 0.876   
http://sift.jcvi.org/[11] Tolerated 0.1 3. 08 SIFT Score. Ranges from 0 to 1. The amino acid substitution is predicted damaging is the score is < = 0.05, and tolerated if the score is > 0.05.
http://provean.jcvi.org/seq_submit.php[12] Neutral -1.027   
http://www.mutationtaster.org/[13] Polymorphism