Identification of a genetic variant at 2q12.1 associated with blood pressure in East-Asians by genome-wide scan including gene-environment interactions

Table 2 SNP with a significant effect on BP when considering interaction between SNP and BMI of the subject

Trait	Interaction	SNP; cytoband; nearby genes; minor allele/major allele	*Type of effect	Discovery (n = 7,486)			Replication 1 (n = 3,703)			Replication 2 (n = 841)			Combined (n = 12,030)
Trait	Interaction	SNP; cytoband; nearby genes; minor allele/major allele	*Type of effect	MAF	Beta (se)	P	MAF	Beta (se)	P	MAF	Beta (se)	P	Beta (se)	P	P_het(Q)
SBP	BMI	^#rs13390641; 2q12.1; TMEM182; A/G	SNP main	0.11	-13.9(3.35)	3.51 × 10^–5	0.10	-11.6 (4.35)	7.73 × 10^–3	0.10	-32.1 (12.5)	1.01 × 10^–2	-14.4 (2.62)	3.83 × 10^–8	0.47 (2.52)
			Interaction		0.56 (0.14)	3.80 × 10^–5		0.47 (0.18)	9.39 × 10^–3		1.35 (0.54)	1.21 × 10^–2	0.59 (0.11)	5.28 × 10^–8	0.48 (2.49)

^#rs13390641 is an imputed SNP in each stage and the effect allele is A; *Type of effect in a linear regression model with SNP × BMI interaction term; SBP, systolic blood pressure; BMI, body mass index; MAF, minor allele frequency; Beta, standardized regression coefficient; se, standard error.
A test of heterogeneity (P_het) was conducted; Q, Cochrane’s Q value based on chi-squared statistics.
Age and sex were covariates in this analysis.

ISSN: 1471-2350