Table 2 Meta-analysis of the association between apolipoprotein E gene ε2/ε3/ε4 polymorphism and glaucoma *
Groups | Sample size | Number of Studies | Test of association | Test of heterogeneity | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | OR(95% CI) | Z | P-value | Model | χ 2 | P-value | I 2(%) | |||
Overall | ε2 vs ε3 | 4765 | 4201 | 15 | 1.08(0.88-1.32) | 0.74 | 0.46 | R | 20.83 | 0.08 | 37.6 |
ε2 carriers vs ε3ε3 | 2001 | 1804 | 14 | 1.02(0.79-1.33) | 0.18 | 0.86 | R | 21.18 | 0.05 | 43.3 | |
ε2ε2 vs ε3ε3 | 1688 | 1541 | 14 | 1.11(0.54-2.28) | 0.28 | 0.78 | F | 3.51 | 0.83 | 0.0 | |
ε4 vs ε3 | 4931 | 4364 | 15 | 1.14(0.86-1.51) | 0.92 | 0.36 | R | 58.45 | <0.0001 | 76.0 | |
ε4 carriers vs ε3ε3 | 2146 | 1955 | 14 | 1.15(0.82-1.59) | 0.81 | 0.42 | R | 50.80 | <0.0001 | 74.4 | |
ε4ε4 vs ε3ε3 | 1704 | 1549 | 14 | 1.66(0.99-2.78) | 1.92 | 0.05 | F | 14.05 | 0.23 | 21.7 | |
Controls in HWE | ε2 vs ε3 | 3994 | 3588 | 11 | 1.03(0.87-1.22) | 0.36 | 0.72 | F | 11.02 | 0.27 | 18.3 |
ε2 carriers vs ε3ε3 | 1790 | 1597 | 11 | 0.93(0.71-1.22) | 0.54 | 0.59 | R | 15.50 | 0.08 | 41.9 | |
ε2ε2 vs ε3ε3 | 1525 | 1359 | 11 | 1.34(0.62-2.90) | 0.73 | 0.46 | F | 2.05 | 0.92 | 0.0 | |
ε4 vs ε3 | 4112 | 3722 | 11 | 1.10(0.83-1.47) | 0.69 | 0.49 | R | 33.90 | 0.0002 | 70.5 | |
ε4 carriers vs ε3ε3 | 1900 | 1723 | 11 | 1.04(0.77-1.42) | 0.26 | 0.79 | R | 29.86 | 0.0009 | 66.5 | |
ε4ε4 vs ε3ε3 | 1533 | 1367 | 11 | 1.41(0.80-2.50) | 1.18 | 0.24 | F | 10.35 | 0.32 | 13.1 | |
Caucasian | ε2 vs ε3 | 2516 | 2342 | 8 | 1.08(0.89-1.31) | 0.74 | 0.46 | F | 7.70 | 0.36 | 9.1 |
ε2 carriers vs ε3ε3 | 996 | 963 | 7 | 1.07(0.84-1.36) | 0.55 | 0.58 | F | 6.65 | 0.35 | 9.8 | |
ε2ε2 vs ε3ε3 | 821 | 813 | 7 | 0.92(0.41-2.09) | 0.20 | 0.84 | F | 2.74 | 0.60 | 0.0 | |
ε4 vs ε3 | 2606 | 2468 | 8 | 0.96(0.81-1.13) | 0.51 | 0.61 | F | 7.89 | 0.34 | 11.3 | |
ε4 carriers vs ε3ε3 | 1079 | 1076 | 7 | 0.93(0.75-1.14) | 0.73 | 0.46 | F | 4.62 | 0.59 | 0.0 | |
ε4ε4 vs ε3ε3 | 823 | 822 | 7 | 0.92(0.47-1.77) | 0.26 | 0.79 | F | 5.52 | 0.36 | 9.3 | |
Asian | ε2 vs ε3 | 2249 | 1859 | 7 | 1.07(0.71-1.62) | 0.32 | 0.75 | R | 13.05 | 0.02 | 61.7 |
ε2 carriers vs ε3ε3 | 1005 | 841 | 7 | 0.95(0.56-1.63) | 0.18 | 0.86 | R | 14.41 | 0.01 | 65.3 | |
ε2ε2 vs ε3ε3 | 867 | 728 | 7 | 2.08(0.45-9.63) | 0.94 | 0.35 | F | 0.04 | 0.98 | 0.0 | |
ε4 vs ε3 | 2325 | 1896 | 7 | 1.53(0.83-2.84) | 1.36 | 0.17 | R | 48.44 | <0.0001 | 87.6 | |
ε4 carriers vs ε3ε3 | 1067 | 879 | 7 | 1.56(0.77-3.13) | 1.24 | 0.21 | R | 45.75 | <0.0001 | 86.9 | |
ε4ε4 vs ε3ε3 | 881 | 727 | 7 | 5.22(1.85-14.68) | 3.13 | 0.002 | F | 2.95 | 0.71 | 0.0 | |
POAG (Caucasian) | ε2 vs ε3 | 1454 | 1404 | 6 | 1.02(0.80-1.30) | 0.13 | 0.90 | F | 6.95 | 0.22 | 28.1 |
ε2 carriers vs ε3ε3 | 522 | 549 | 5 | 0.99(0.72-1.37) | 0.05 | 0.96 | F | 5.92 | 0.20 | 32.5 | |
ε2ε2 vs ε3ε3 | 426 | 457 | 5 | 0.79(0.26-2.44) | 0.41 | 0.68 | F | 0.56 | 0.76 | 0.0 | |
ε4 vs ε3 | 1522 | 1478 | 5 | 1.04(0.84-1.28) | 0.34 | 0.74 | F | 6.56 | 0.26 | 23.8 | |
ε4 carriers vs ε3ε3 | 581 | 613 | 5 | 1.01(0.76-1.33) | 0.05 | 0.96 | F | 3.59 | 0.47 | 0.0 | |
ε4ε4 vs ε3ε3 | 430 | 463 | 5 | 1.24(0.55-2.77) | 0.52 | 0.60 | F | 3.05 | 0.38 | 1.6 | |
POAG (Asian) | ε2 vs ε3 | 2091 | 1859 | 7 | 0.96(0.75-1.22) | 0.34 | 0.73 | F | 6.27 | 0.28 | 20.2 |
ε2 carriers vs ε3ε3 | 953 | 841 | 7 | 0.78(0.48-1.27) | 1.00 | 0.32 | R | 10.68 | 0.06 | 53.2 | |
ε2ε2 vs ε3ε3 | 827 | 728 | 7 | 2.08(0.45-9.63) | 0.94 | 0.35 | F | 0.04 | 0.98 | 0.0 | |
ε4 vs ε3 | 2149 | 1896 | 7 | 1.45(0.82-2.55) | 1.29 | 0.20 | R | 37.92 | <0.0001 | 84.2 | |
ε4 carriers vs ε3ε3 | 1000 | 879 | 7 | 1.45(0.76-2.76) | 1.13 | 0.26 | R | 36.86 | <0.0001 | 83.7 | |
ε4ε4 vs ε3ε3 | 838 | 727 | 7 | 4.98(1.75-14.20) | 3.01 | 0.003 | F | 3.01 | 0.70 | 0.0 | |