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Table 3 Mutation detection rate according to inclusion criteria

From: Hereditary breast and ovarian cancer: assessment of point mutations and copy number variations in Brazilian patients

Hereditary Breast and Ovarian Cancer (HBOC) Distribution by criterion Number of mutation carriers Positive detection rate
1. BC ≤ 45 years of age (no family history) 11 0 0%
2. BC ≤ 45 years of age with ≥ 1 relative with BC, OC, FTC and PPC at any age 42 14 33%
3. BC < 45 ≤ 50 years of age with ≥ 1 relative with BC, OC, FTC and PPC ≤ 50 years of age 16 2 12%
4. BC >50 years of age with ≥ 1 relatives with BC, OC, FTC and PPC at any age 28 5 18%
5. Two BC when the first occurrence was prior to age 50 5 1 20%
6. BC at any age plus OC, FTC and PPC at any age 9 4 44%
7. Ashkenazi Jewish ancestry 5 4 80%
8. OC, FTC and PPC at any age 3 1 33%
9. Male BC 1 0 0%
  1. BC: Breast cancer; OC: ovarian cancer; FTC: Fallopian tube cancer; PPC: Primary peritoneal cancer.