Hereditary Breast and Ovarian Cancer (HBOC) | Distribution by criterion | Number of mutation carriers | Positive detection rate |
---|---|---|---|
1. BC ≤ 45 years of age (no family history) | 11 | 0 | 0% |
2. BC ≤ 45 years of age with ≥ 1 relative with BC, OC, FTC and PPC at any age | 42 | 14 | 33% |
3. BC < 45 ≤ 50 years of age with ≥ 1 relative with BC, OC, FTC and PPC ≤ 50 years of age | 16 | 2 | 12% |
4. BC >50 years of age with ≥ 1 relatives with BC, OC, FTC and PPC at any age | 28 | 5 | 18% |
5. Two BC when the first occurrence was prior to age 50 | 5 | 1 | 20% |
6. BC at any age plus OC, FTC and PPC at any age | 9 | 4 | 44% |
7. Ashkenazi Jewish ancestry | 5 | 4 | 80% |
8. OC, FTC and PPC at any age | 3 | 1 | 33% |
9. Male BC | 1 | 0 | 0% |