Table 1 Analysis of genetic effect of ADH1B His47Arg and ALDH2 Glu487Lys on the risk of various diseases in a Korean population (n = 6,423)
From: Functional polymorphism in aldehyde dehydrogenase-2 gene associated with risk of tuberculosis
Loci | Disease | Group | Genotype | Total N | MAFa | HWEb | OR (95% CI)c | Pc | ||
|---|---|---|---|---|---|---|---|---|---|---|
His/His | His/Arg | Arg/Arg | ||||||||
ADH1B His47Arg | Hepatitis | CCd | 317(59.0%) | 196(36.5%) | 24(4.5%) | 537 | 0.227 | 0.361 | 0.95 (0.76-1.18) | 0.64 |
SRd | 243(57.1%) | 165(38.7%) | 18(4.2%) | 426 | 0.236 | 0.125 | ||||
Asthma | Case | 708(56.2%) | 464(36.9%) | 87(6.9%) | 1259 | 0.253 | 0.358 | 0.99 (0.84-1.17) | 0.91 | |
Control | 295(54.8%) | 210(39.2%) | 32(6.0%) | 537 | 0.256 | 0.503 | ||||
T2DM | Case | 449(60.3%) | 251(33.7%) | 45(6.0%) | 745 | 0.229 | 0.214 | 0.91 (0.76-1.08) | 0.28 | |
Control | 349(56.8%) | 227(37.0%) | 38(6.2%) | 614 | 0.247 | 0.893 | ||||
Alcoholisme | Case | 217(39.5%) | 145(26.4%) | 187(34.1%) | 549 | 0.473 | 3.172 × 10 -28 | 2.38 (2.00-2.82) | 1.28E-22 | |
Control | 298(61.7%) | 155(32.1%) | 30(6.2%) | 483 | 0.223 | 0.893 | ||||
TB | Case | 273(57.2%) | 169(35.4%) | 35(7.4%) | 477 | 0.251 | 0.217 | 1.01 (0.84-1.22) | 0.89 | |
Control | 450(56.5%) | 297(37.3%) | 49(6.2%) | 796 | 0.248 | 0.999 | ||||
ALDH2Glu487Lys | Hepatitis | CC | 372(69.3%) | 157(29.2%) | 8(1.5%) | 537 | 0.161 | 0.058 | 1.02 ( 0.80-1.31) | 0.88 |
SR | 305(71.6%) | 107(25.1%) | 14(3.3%) | 426 | 0.158 | 0.230 | ||||
Asthma | Case | 860(68.3%) | 358(28.4%) | 41(3.3%) | 1259 | 0.175 | 0.617 | 1.17 (0.96-1.41) | 0.12 | |
Control | 385(71.7%) | 139(25.9%) | 13(2.4%) | 537 | 0.154 | 0.914 | ||||
T2DM | Case | 498(66.8%) | 224(30.1%) | 23(3.1%) | 745 | 0.181 | 0.718 | 1.05 (0.87-1.28) | 0.60 | |
Control | 426(69.4%) | 163(26.5%) | 25(4.1%) | 614 | 0.173 | 0.066 | ||||
Alcoholisme | Case | 530(96.5%) | 19(3.5%) | 0(0.0%) | 549 | 0.017 | 0.680 | 0.10 (0.06-0.16) | 3.88E-20 | |
Control | 346(73.6%) | 122(25.3%) | 15(3.1%) | 483 | 0.265 | 0.297 | ||||
TB | Case | 391(82%) | 78(16.4%) | 8(1.7%) | 477 | 0.099 | 0.082 | 0.57 (0.45-0.74) | 0.00001 | |
Control | 559(70.2%) | 216(27.1%) | 21(2.6%) | 796 | 0.162 | 0.980 | ||||