Figure 1
From: Novel SPAST deletion and reduced DPY30 expression in a Spastic Paraplegia type 4 kindred
![Figure 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1471-2350-15-39/MediaObjects/12881_2014_Article_1185_Fig1_HTML.jpg)
( Top ) Family pedigree. The arrow indicates the index case. Squares, men; Circles, women. Black symbols indicate clinically affected individuals; empty symbols show clinically healthy relatives. Carriers of the novel mutation in SPG4/SPAST are indicated with a dotted frame. Star symbols indicate individuals who underwent DNA studies but then tested normal. (Bottom) Electropherogram flanking the novel mutation c.1-763_c.683-650del affecting the 5′UTR and exons 1–4 of SPAST, and the position of spastin neighboring genes.